摘要
对４８例大肠癌病人外周血、肿瘤及癌旁粘膜匀浆中胃泌素、生长抑素（ＳＳ）水平行ＲＩＡ测定。结果表明：癌患者平均血清胃泌素（ＳＧ）水平显著高于对照组（Ｐ＜０．０５），肿瘤切除后明显下降（Ｐ＜０．０５）；分组比较表明ＤｕｋｅｓＣ期和直肠癌病人平均ＳＧ水平显著高于对照组（Ｐ＜０．０５）；肿瘤及癌旁粘膜中胃泌素水平很低，无法测出。癌患者平均血浆ＳＳ（ＰＳＳ）水平显著高于对照组（Ｐ＜０．０５）；分组比较表明ＤｕｋｅｓＢ期和粘液腺癌病人平均ＰＳＳ水平显著高于对照组（Ｐ＜０．０５）；癌远旁粘膜（距肿瘤５～１０ｃｍ）平均ＳＳ水平高于癌组织，低于癌近旁（距肿瘤＜２ｃｍ）粘膜，三者间相差均非常显著（Ｐ＜０．０１）。ＳＧ与癌近旁ＳＳ水平间、ＰＳＳ与肿瘤ＳＳ水平间均呈非常显著之正相关（Ｐ＜０．０１）。
In 48 colorectal cancer patients, the authors determined the levels of gastrin, sonatostatin (SS) in the peripheral blood, tumor tissue and the adjacent mucosa with RIA. It was found that the mean value of serum gastrin (SG) in cancer patients was significantly higher than that in controls (P<0. 05) and decreased significantly after the tumor was removed (P<0. 05). Significantly higher level was also noticed in patients with Dukes C cancer (P<0.05). Tumor gastrin levels, as well as the surrounding mucosa were too low in content to be detected. The mean plasma SS level was significantly higher in cancer patients than in controls (P<0.05). It was also significantly higher in patients with cancer in Dukes B stage or mucinous adennocarcinoma than in controls (P<0. 05). The mean SS level in mucosa 5￣10cm from the tumor was very much higher than that in the tumor and lower than that in the cancer-adjacent mucosa (<2cm from the tumor) (P<0. 01). There was 8 very close correlation between the SG and SS levels in cancer-adjacent mucosas, and between plasma SS levels and the SS levels in tumors (P<0. 01).
出处
《中国肿瘤临床》
CSCD
北大核心
1996年第10期688-691,共4页
Chinese Journal of Clinical Oncology
