摘要
107例急性心肌梗塞患者按住院顺序为Ⅰ组(n=57)和Ⅱ组(n=50)行尿激酶静脉溶栓”治疗。Ⅱ组患者在溶栓治疗前后予开搏通口服。其中Ⅰ组(对照组)再通32例,Ⅱ组(治疗组)再通26例。结果:1.CK-MB、CK峰值、溶栓治疗后4小时内加速性心室自主节律和室速的发生率,治疗组均低于对照组(P<0.01)。2.溶栓治疗后4、12、24、72小时的血浆丙二醛浓度,对照组均显著高于溶栓治疗前(P<0.01);而治疗组溶栓治疗前后则无差异(P>0.05)。提示:开搏通可防治氧自由基导致的人缺血心肌再灌注损伤。
The purpose of this study was to determine whether captopril has protective effects on reperfusion injury or not. 107 consecutive acute myocardial infarction (AMI)patients were randomized to group Ⅰ (control group,n=57)and group Ⅱ(n=50). Intravenous thrombolytic therapy with urokinse was conducted in all patients. Before and after the thromblysis the patients of group Ⅱ received captopril. The patency of the infarct-related coronary artery in group Ⅰ and group Ⅱ were 32 and 20 patients respectively. The results of the study were showed as follows; 1. Both the peak activity of creatine kinase (CK),CK-MB isoenzyme and the occurrence rate of accelerated idio-ventricuiar tachycardia (VT) in treatment group was significantly lower than the control group(P<0. 01). 2. At the time of 4,12,24, 72 hrs after the thromblysis the concentration of the plasma malonyldiaidehyde (MDA) in control group were higher than that before thrombiysis(P<0. 01),which were unchanged in treatment group (P>0. 05). The results suggested that captopril protect ischemic heart from reperfuion injury caused by oxygen free radicals.
出处
《天津医药》
CAS
1996年第11期651-654,共4页
Tianjin Medical Journal
基金
山东省科委青年科研基金
关键词
心肌缺血
再灌注损伤
开搏通
ischemic myocardium reperfusion injury acute myocardiai infarction cap-topril
