摘要
目的研究脑心通胶囊对血管性痴呆(VD)大鼠学习记忆能力和海马细胞形态的影响。方法采用大脑中动脉梗死(MCAO)法制成VD大鼠模型后随机分为脑心通组(中药组)、西药组、模型组,另设假手术组和正常组,共治疗28d,治疗后以Morris水迷宫实验检测其学习记忆行为能力,以HE染色、Nissl染色检测其细胞形态的变化。结果脑心通胶囊可以改善VD大鼠学习记忆能力,明显减轻缺血对海马CA1区锥体细胞的损伤。结论脑心通胶囊为治疗VD大鼠的有效方,其治疗机制可能与减轻缺血对海马CA1区锥体细胞的损伤有关。
Objective To explore the effect of Naoxintong capsule on learning and memory ability and pathological morphologic features of vascular dementia in rats. Methods The rat models of vascular dementia was built up by middle cerebral artery occlusion （MCAO）. The rats were divided into Naoxintong group （treated by traditional Chinese medicine）, Western medicine group and model group randomly. Sham operation group and normal group were prepared. The rats were treated for twenty-eight days, then their learning ability and memory were tested by Morris water maze experiment and the changes of cell morphology were detected by HE stain and Nissl stain. Results Naoxintong Capsule could improve the learning ability and memory, lessen the injury of pyramidal cells on CA1 field in hippocarnpus in rats with vascular dementia. Conclusions Naoxintong Capsule was effective prescription for vascular dementia in rats. The therapeutic mechanism concerned with lessening the injury of pyramidal cells on CA1 field in hippocampus, which might related to metabolic effect.
出处
《中西医结合心脑血管病杂志》
2006年第1期35-36,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
