摘要
目的:探讨血管性假血友病因子(vWF)基因19内含子M spⅠ的多态性与妊娠期高血压疾病蛋白尿的发生及血压之间的关系。方法:采用聚合酶链反应-限制性内切酶片断长度多态性(PCR-RFLP)技术,检测70例妊娠期高血压疾病患者的vWF基因19内含子M spⅠ的多态性位点频率。结果:M-/M-基因型患者血压比M+/M+和M+/M-基因型两组患者血压低,而尿蛋白阳性率则更高。P<0.05。结论:vWF基因19内含子M spⅠ酶切位点多态性可能与妊娠期高血压病临床症状有关。
Objective： In order to ascertain the relationship between yon Willebrand factor gene MspI polymorphism in intron 19 and the symptoms of hypertensive disorder complicating pregnancy among Chineses. Methods： Msp I polymorphism was studied by PCR and Msp I digestion in 70 cases with hypertensive disorder complicating pregnancy. Results. The blood pressure of M -/M - genotype is higher than M ＋/M ＋ and M ＋/M - genotypes and the frequencie of proteinuria is lower than another groups. Conclusion ： MspI polymorphism in intron 19 in the yon Willebrand factor gene may be associated with the hypertension and proteinuria of hypertensive disorder complicating pregnancy among Chinese.
出处
《中国妇幼保健》
CAS
北大核心
2006年第15期2142-2144,共3页
Maternal and Child Health Care of China
