摘要
目的：观察使用甲氨蝶呤（methotrexate，MTX）与米非司酮（mifepristone）序贯给药治疗异位妊娠的可行性。方法：异位妊娠确诊患者132例，按MTX40mg／m。的剂量肌注，12～24h再给予米非司酮300mg顿服；间隔3～5天，如疗效不显著可重复治疗，最多用药可达4次。采用免疫荧光法（参考值≤2．9IU／L）检测治疗前后血β-HCG的变化。结果：大部分病例给药后血β—HCG有不同程度的下降，132例患者中有119例达到治愈标准，占90．1％。结论：应用MTX与米非司酮序贯给药是治疗异位妊娠的有效方法。
Objective： To investigate the curative effect of sequential treatments with methotrexate and mifepristone for ectopic pregnancy. Methods： 132 cases in our hospital from November 2001 to May 2003 were diagnosed ectopic pregnancy. Methotrexate was given as standard as 40 mg/m2 i. m and mifepristone was taken orally 12 hours later and the sequential treatments were repeated not more than 4 times each 5 days. Serum β - HCG level was detected by immunofluorescence. Results： The serum β - HCG level of most of the cases descended by different levels. 119 cases of the 132 cases reached the level of recovery. The recovered rate was 90. 1%. Conclusion： The sequential therapy with methotrexate and mifepristone is an effective method for the treatment to ectopic pregnancy.
出处
《中国妇幼保健》
CAS
北大核心
2006年第15期2113-2114,共2页
Maternal and Child Health Care of China
关键词
甲氨蝶呤
米非司酮
序贯用药
异位妊娠
Methotrexate
Mifepristone
Sequential therapy
Ectopic pregnancy
