摘要
目的观察恶性肿瘤化疗治疗时添加副反应抑制剂以增加治疗依从的临床疗效。方法对105例恶性肿瘤患者随机分为含骨髓抑制剂甲地孕酮的化疗治疗组54例和单纯化疗治疗的对照组51例。结果治疗组的中性白细胞减少率和厌食发生率分别为43%和46%,显著低于对照组的63%和67%(P均<0.05);治疗组和对照组的客观缓解率无统计学差异,但是治疗组的临床获益反应率显著高于对照组(67%和47%,P<0.05)。结论应用适当剂量的副反应抑制剂改善化疗期癌症患者的生活质量,提高治疗依从性,疗效确切,值得临床推广应用。
Objective To analyze the effect of chemotherapy plus megestrol acetate on malignant tumor patients. Methods 105 patients with malignant tumors were randomly divided into observation group consisted of 54 eases treated with chemotherapy plus megestrol acetate and control group consisted of 51 cases receiving chemotherapy alone. Results The incidence rate of neutropenia was 43% and 63% in the control group,showing significantly difference （ P 〈 0.05）. The incidence rate of anorexia was 46% in the treatment group and 67% in the control group, also showing significant difference （ P 〈 0.05）, There no significant improvement was observed in the treatment group as compared with that of the control group. However, clinical benefit rate was 67% in the treatment group and 47% in the control group ,showing significant difference （ P 〈 0.05）. Conclusion Megestrol Acetate is an ideal adjuvant and it can improve the life quality of the malignant tumor patients once used with an appropriate dose.
出处
《中国热带医学》
CAS
2006年第8期1435-1435,1531,共2页
China Tropical Medicine
关键词
恶性肿瘤
生活质量
化疗
Malignant tumor
Life quality
Chemotherapy
