摘要
采用放射免疫法对３３例正常人（对照组）和６２例肺结核患者进行血清肿瘤坏死因子（ＴＮＦ）含量的测定。结果表明：对照组血清ＴＮＦ含量为１４．８０±０．７２ｆｍｏｌ／ｌ．肺结核患者治疗前血清ＴＮＦ含量为１６．６０±１．１１ｆｍｏｌ／ｌ，显著高于对照组（Ｐ＜０．００１）。肺结核患者经治疗后血清ＴＮＦ含量为１３．９０±１．１２ｆｍｏｌ／ｌ，显著低于对照组（Ｐ＜０．０１）。且治疗二个月后进展期肺结核患者血清ＴＮＦ含量为１４．７０±１．８１ｆｍｏｌ／ｌ，明显高于治疗二个月后好转期肺结核患者血清ＴＮＦ含量１３．４０±１．０３ｆｍｏｌ／ｌ（Ｐ＜０．０１）。说明ＴＮＦ与肺结核患者的病情及发病机制有关，所以检测血清ＴＮＦ含量对结核病的发病机理、病情判断及疗效观察具有一定的临床意义。
Adopting radioimmunoassay, the serum TNF of 33 normal persons and 62 pulmonary TB potierltsare determined. The results are as foliows: the serum TNF content of normal persons is 14. 80±0. 72fmol/l, while the serum TNF of pulmonary TB patients is 16. 60±1.11 fmol/l before treatment. Obviously, the value is higher than that of normal normal persons. The serum TNF content of pulmonary TB patients is 13. 90±1.12 fmol/l after treatment and the value is obviously lower than that of normal persons. Furthermore, after two month treatment the serum TNF content of progresive-stage pulmonaryTB patientS is 14. 70±1. 81 fmol/l. The value is obviously higher than that of resolving-stage pulmonary TB patients 13. 40±1. 03 fmol/l after two month treatment (P<0.01). It shows that TNFis concerned with the condition and pathogeny of pulmonary TB patients. So the determination ofserum TNF has clinical significance to pathogeny. judgement and curative effect observation of pulmonary TB.
出处
《同位素》
CAS
北大核心
1996年第3期164-166,共3页
Journal of Isotopes
关键词
肺结核
肿瘤坏死因子
放射免疫测定
pulmonary tuberculosis tumor necrosis factor (TNF) radioimmunoassay
