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孕妇外周血胎儿游离DNA的检测及应用研究 被引量：1

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摘要 从1997年首次在孕妇外周血中发现胎儿DNA以来,众多学者致力于将其应用于无创性的产前诊断。荧光定量PCR实现了胎儿游离DNA浓度的检测,目前研究发现,正常孕妇血浆胎儿DNA浓度稳定于某一水平,有望成为产前诊断和孕期检测的一项新指标。有学者认为,子痫前期母循环中胎儿DNA可有异常增高,而且子痫前期的孕妇在有临床症状前,孕妇血浆胎儿DNA水平异常增高,这与较多胎儿DNA释放到母血中,和肝肾功能异常导致胎儿DNA在母血中清除紊乱有关。此外许多妊娠合并症和并发症都伴有母外周血DNA水平的异常增高,例如:性连锁疾病、Rh血型不合、父系遗传性疾病、染色体非整倍体胎儿、早产等。现就孕妇外周血胎儿游离DNA的检测及临床应用作一综述。
作者 陶红 王雪梅 纪向虹
机构地区 青岛市市立医院妇产科
出处 《现代妇产科进展》 CSCD 北大核心 2006年第6期461-464,共4页 Progress in Obstetrics and Gynecology
关键词 产前诊断 外周血 孕妇 游离DNA 胎儿
分类号 R714.7 [医药卫生—妇产科学]
  • 相关文献

参考文献20

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同被引文献22

  • 1苏放明.染色体畸变的产前诊断技术与风险[J].实用妇产科杂志,2006,22(3):132-134. 被引量：1
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  • 4Wataganara T,Chen AY,Leshane ES,et al.Cell-free fetal DNA levels in maternal plasma after elective first-trimester termination of pregnancy.Fertil Steril,2004,81:638～644.
  • 5Ohashi Y,Mihan N,Honda H,et al.Correlation of fetal DNA and human chorionic gonadotrop in concentration.Clin Chem,2002,48:386～388.
  • 6Lo YM,Lau TK,Poon PM,et al.Quantitative analysis of fetal DNA in meternal plasma and serum:implications for noninvasive prenatal diagnosis.Am J Hum Genent,1998,62 (4):768～775.
  • 7Chan KC,Zhong J,Hui AB,et al.Size distributions of maternal and fetal DNA in maternal plasma.Clin Chem,2004,50:88～92.
  • 8Lo YM,Zhang F,Leung TN,et al.Rapid clearance of fetal DNA from maternal plasma.Am J Hum Genet,1999,64:218～224.
  • 9Rijnder RJ,Christiaens GC,Bossers B,et al.Clinical applications of cell-free fetal DNA from maternal plasma.Obstet Gynecol,2004,103:157～164.
  • 10Harper JC,Fining KM,Martin P,et al.Use of maternal plasma for noninvasive determination of fetal RhD status.Am J Obstet Gynecol,2004,191:1730～1732.

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现代妇产科进展
2006年 第6期

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