摘要
目的：用实验法测出利福平水溶液最稳定ｐＨ及３种缓冲剂对利福平水溶液稳定性的影响。方法：用恒温加速实验法研究利福平的稳定性。按中国药典（１９９０年版）法测定利福平的含量，对实验数据进行配对ｔ检验。结果：绘制出ｐＨ－速度图，利福平含量配对ｔ检验结果表明：含醋酸盐和硼酸盐缓冲剂两组相比，无显著性差异（Ｐ＞０．０５），而含磷酸盐组与含硼酸盐或醋酸盐组相比，差异显著（Ｐ＜０．０５）。结论：利福平水溶液最稳定ｐＨ为６．０～７．０。利福平在硼酸盐或醋酸盐缓冲液中比在磷酸盐中稳定。
OBJECTIVE:To study the most stable pH value of rifampicin solution and effects of three kinds of buffers on the stability of rifampicin solution.METHOD:The stability of rifampicin was studied by classic method.The content of rifampicin solution was determined by Chinese pharmacopoea method(1990).The figure of pH lgk was done.RESULTS:The most stable pH value of rifampicin solution was observed.The paried t test for content of rifampicin indicated that rifampicin solution of acetate and borate had no significant difference(P>0.05),but the content of phosphate and acetate or borate had significant difference(P<0.05).CONCLUSION:The most stable pH value of rifampicin solution is 6.0～7.0.The laboratory findings showed that rifampicin is more stable in borate or acetate buffer than in phosphate.Phosphate makes rifampicin to break up rapidly.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1996年第7期406-409,共4页
Chinese Pharmaceutical Journal
