摘要
α和β双炔失碳酯绝对构型与生物活性的初步探讨李麟谢宁李正化（华西医科大学药学院，成都６１００４１）双炔失碳酯（２ξ，１７ξ二乙炔基Ａ环失碳５α雄甾烷２β，１７β二醇二丙酸酯）是我国研制并已广泛应用的一种避孕药［１］。它的差向异构体...
The molecular structures and absolute configurations of α and β anordrins are reported. Animal experiments showed that pure α epimer possessed high anti implantation and anti early pregnancy effects, but the pure β epimer exhibited very low effects at the same dose. MNDO program was applied for the optimization of the configurations of epimers to establish the isolated molecular configurations and calculate the quantum chemical indexes. The results showed that the configurations and the differences of action field in three dimensions of α and β epimer are probably the factors that the α epimer exhibited biological activity.
出处
《药学学报》
CAS
CSCD
北大核心
1996年第7期554-557,共4页
Acta Pharmaceutica Sinica
