摘要
以ＨＢｓＡｇ、ＨＢｅＡｇ阳性孕妇作为研究对象，用病例。对照研究方法，比较婴儿乙型肝炎疫苗免疫失败和婴儿疫苗免疫成功两组孕妇分娩时血清乙型肝炎病毒ＨＢＶ－ＤＮＡ含量，进一步用定群方法研究母亲ＨＢＶ－ＤＮＡ含量与其婴儿免疫后ＨＢｓＡｇ持续携带率的关系，证实孕妇血清ＨＢＶ－ＤＮＡ高含量是婴儿免疫失败的主要原因。根据孕妇血清ＨＢＶＤＮＡ含量可预测婴儿常规疫苗免疫失败的危险度。为改进乙型肝炎免疫减少免疫失败比例提供指针。
hepurposeofthisprojectistostudytheimpactofmaternalserumHBVDNAcontentsonthefailurewithhepatitisBvaccineinpreventingperinataltransmissionofhepatitisBvirusininfants.HBeAlgpositivepregnantwomenandtheirinfantswerestudied,MaternalserumHBVDNAcontentsininfantswithvaccinefailurewerecomparedwiththoseininfantswithvaccinesuccess.Inaddition,acohortstudywasconductedwherethematernalHBVDNAlevelwasmeasuredandtheirin-fantswerefollowedupforHBVcarrierrate.TheresultsshowedthathighmatemalHBVDNAlevelwuapredominantrtlskfactorfortheimmunizationfailuce.ThematernalHBVDNAcontentisthususedaspredictionoftheriskoffailureininfantswithroutinehepatitisBimmunizationschedule.
出处
《中华实验和临床病毒学杂志》
CSCD
1996年第3期267-270,共4页
Chinese Journal of Experimental and Clinical Virology
