摘要
运用益元活血方治疗老年人腔隙性梗塞（Ｌ１）并观察该方对血小板最大聚集率（ＭＡＲ）、血栓素Ｂ２（ＴＸＢ２）和６－酮－前列腺素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）的作用。结果表明：益元活血方治疗组的疗效优于对照组（Ｐ＜０．０１）。Ｌ１组ＭＡＲ、ＴＸＢ２和ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值均高于健康组（Ｐ＜０．０１～０．００１）。治疗组和对照组用药后，ＭＡＲ、ＴＸＢ２和ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值均低于用药前（Ｐ＜０．０５～０．００１）；治疗组用药后ＭＡＲ、ＴＸＢ２和ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值的降低与对照组比较有显著差异（Ｐ＜０．０５～０．０１）。提示：益元活血方治疗老年人Ｌ１的机理与其抑制血小板活化和调节血栓素与前列环素平衡失调有关。
Treatment of lacunae infarcts (L 1) in the aged with Yiyuan Houxue Fang(YHF)and the effect of YHF on maximum platelet aggregation ratio(MAR),plasma TXB 2 and 6-keto-PGF 1α were studied.It was found that the clinical effect of YHF was better than control's.The MAR,TXB 2 and TXB 2/6-keto-PGF 1α ratio were higher in L1's than those in the heathy group.The level of MAR,TXB 2 and TXB 2/6-keto-PGF 1α ratio were lower after treating than befer treating in YHF's and control.The decreasement of MAR,TXB 2 and TXB 2/6-keto-PGF 1α ratio were significant in YHF's than those in control.It was suggested that the mechanism with it YHF's treating L1 in the aged was related to YHF's in hibiting platelet activation and regulating the balance between TXA 2 and PGI 2.
出处
《辽宁中医杂志》
CAS
北大核心
1996年第12期531-532,共2页
Liaoning Journal of Traditional Chinese Medicine
关键词
脑梗塞
血栓素
前列环素
老年人
益元活血方
Lacunae infarets\ Platelet function\ Thromboxane \ Prostacyclin\ Aged\ Yiyuan Houxue Fang
