摘要
为研究平喘中药对气道的作用，我们测得致敏性哮喘豚鼠支气管灌洗液（ＢＡＬＦ）白蛋白、细胞总数及嗜酸性粒细胞数均比正常对照组豚鼠明显增多（Ｐ＜０．０１）。淋巴毒素Ｃ＿４（ＬＴＣ＿４）及Ｅ＿４（ＬＴＥ４）比对照组增高（Ｐ＜０．０５）。致敏豚鼠在吸入过敏原促发哮喘前腹腔注入平喘中药（麻黄、百部、地龙、杏仁和防风），而哮喘时ＢＡＬＦ的白蛋白、细胞总数及嗜酸性粒细胞比未用中药的哮喘组明显下降（Ｐ＜０．０１），ＬＴＣ＿４和ＬＴＥ＿４也有所下降（Ｐ＜０．０５）。结果显示平喘中药能抑制嗜酸性粒细胞增多，减少内皮损伤和白蛋白渗出。表明平喘中药在哮喘发作时，对气道具有重要保护作用。
In order to investigate the effect of traditional Chinese medicine on airway,we measuredbronchoalvealar lavage fluid(BALF)of asthmatic guinea pigs before and after in jecting tra-ditional Chinese medicine in the abdomen cavity during the episode of asthma. The resultsrevealed that the total number of cells and number of eosin ophils in BALF were increased af-ter exposure to allergen in sensitized guinea pigs compared to those in control animals(P<0.01).The level of albumin in BALF of sensitized guinea pigs was higher than those of con-trol animals(P<0.01).Levels of leukotrienes C_4 and E_4 were higher than those of controlanimals(P<0.05). After injected with the medieines(including Lumbricus, Radix Stemonae,Semen Arme-niacae Amarum,Herba Ephedra and radix Ledebouriellae),indices of cell were decreased(P<0.01),level of albumin(P<0.01),Leutrienes C_4 and E_4 were lower than the group with-out injection(P<0.05).These results suggested that the traditional Chinese medicine couldinhibit airway eosinophilia, diminish the epithelial damage and effusion of Albumin,The ex-periment showed that the traditional Chinese medicine have important protective effect on theairway in episodes of asthma.
出处
《上海医学》
CAS
CSCD
北大核心
1996年第11期638-641,共4页
Shanghai Medical Journal
关键词
支气管肺
泡灌洗液
中草药
哮喘
气道
Eosinophilia
Leukotrienes(LT)
Bronchoalvealar Lavage Fluid(BALF)
Traditional Chinese Medicine
