运动应激所致血清IL-1β和IL-6浓度增加及其作用研究被引量：5

Study on Function and Increasing of Serum Concentration about IL-1β and IL-6 Induced by Exercise Stress

下载PDF

导出

摘要目的:探索运动应激时血清白细胞介素-1β(IL-1β)和白细胞介素-6(IL-6)浓度变化及其与糖代谢和细胞免疫的关系。方法:非体育专业男大学生,空腹,以200W蹬车2min,间歇5min,重复运动至极度疲劳。检测运动前、运动后即刻和运动后3h血清IL-1β、IL-6、皮质醇(Cor)、血糖(GLU)和血乳酸(BLA)浓度以及T-淋巴细胞转换指数(T-LTI)变化。结果:在运动后即刻,血清GLU、BLA、IL-1β、IL-6和Cor浓度增加幅度分别达运动前的40%、314%、75%、110%和95%(P<0.001),而T-LTI则下降了31%(P<0.001),经3h休息,Cor、GLU和T-LTI未完全恢复,但BLA、IL-1β和IL-6基本恢复;IL-1β、IL-6、Cor分别与GLU和BLA呈正相关(P<0.05),但与T-LTI均呈负相关(P<0.05);Cor分别与IL-1β和IL-6呈正相关(P<0.05)。结论:IL-1β和IL-6在运动应激期间主要参与糖代谢的调节,对细胞免疫功能有一定抑制作用。 The purpose of this study was to explore the change of serum concentration of interleukin-1β（IL-1β） and IL-6, and the relationship with glucose metabolize and cellular immunity during exercise stress. Male college students of non-physical education major exercised contlnuously for two minutes ,rested for five minutes on 200 watts treadmill,repeated exercise till fatigue under empty stomach. Serum concentration of IL-1β,IL-6,cortisol （Cot）, glucose （GLU） and lactic acid （BLA） and T-lymophcyte were detected before exercise and right after exercise for three hours. The result showed that right after exercise,the concentration of GLU,BLA,IL-1β IL-6 and Cor reached the level of 40%,314%,75%,110% and 95% of that before exercise, while the level of the T-LTI decreased the 31%. After three hours rest, the Cor,GLU and T-LTI was completely to recover to normal level,but the BLA, IL-1β and IL-6 got basic recovery. IL-1β, IL-6, Cot had positive correlation with GLU and BLA, but had negative correlation with T-LTI. It concluded that IL-1β and IL-6 involved in the regulation of glucose metabolism,and had certain inhibition on cellular immunity.

作者何伟

机构地区四川师范大学体育学院

出处《体育科学》 CSSCI 北大核心 2006年第7期33-35,74,共4页 China Sport Science

关键词运动应激白细胞介素-1Β 白细胞介素-6 血糖 T-淋巴细胞转换指数 exercise stress interleukin- 1β （ IL- 1β） IL- 6 glucose T-lymophcyte transformation index

分类号 G804.32 [文化科学—运动人体科学]

引文网络
相关文献

参考文献10

1何伟.运动与细胞因子的研究进展[J].体育科学,2005,25(7):63-67. 被引量：14
2孙卫民，王惠琴.细胞因子研究方法[M]．北京：人民卫生出版社，1997．
3ALBERT MORASKA, JAY CAMPISI, KIEN T NGUYEN, et al. Elevated IL-1 Contributes to Antibody Suppression Produced by Stress[J]. J Appl Physiol, 2002,93 (6) : 207-215.
4PEDERSEN B K,LAURIE HOFFMAN-GOETZ. Exercise and the Immune System: Regulation, Integration, and Adaptation[J]. Physiol Rev,2000,80:1055-1081.
5何伟高强.不同强度运动引起的血浆K^+、Na^+变化及其对表面肌电图的影响[J].中国运动医学杂志,1998,17(1):94-94.
6ANDREI I MOLDOVEANU, ROY J SHEPHARD, PANG NSHEK. Exercise Elevates Plasma Levels but not Gene Expression of IL-1β,IL-6,and TNF-α in Blood Mononuclear Cells[J].J Appl Physiol,2000,89: 1499-1504.
7H ULLUM,P M HAAHR,M DIAMANT,et al. Bicycle Exercise Enhances Plasma IL-6 but Does not Change IL-1alpha,IL-1beta, IL-6, or TNF-alpha Pre-mRNA in BMNC[J]. J Appl Physiol, 1994,77:93-97.
8M A. FEBBRAIO, B K PEDERSEN. Muscle-derived Interleukin-6:Mechanisms for Activation and Possible Biological Roles [J]. FASEB J, 2002,16: 1335-1347.
9KATSUHIKO SUZUKI,MANABU TOTSUKA, SHIGEYUKI NAKAJI,et al. Endurance Exercise Causes Interaction Among Stress Hormones, Cytokines, Neutrophil Dynamics, and Muscle Damage[J]. J Appl Physiol,1999,87:1360-1367.
10何伟,高强.运动与白细胞介素[J].中国运动医学杂志,1995,14(4):233-237. 被引量：20

二级参考文献62

1PEDERSEN B K,LAURIE HOFFMAN-GOETZ. Exercise and the Immune System: Regulation, Integration, and Adaptation[J]. Physiol Rev, 2000,80: 1055-1081.
2MICHAEL GLEESON. Interleukins and Exercise [J]. J Physiol,2000,529 : 1 ppl-1.
3STEENSBERG A, VAN HALL, G OSADA,et al. Production of IL-6 in Contracting Human Skeletal Muscles Can Account for the Exercise-induced Increase in Plasma IL-6 [J]. J Physiol,2000,529:237-242.
4LARS ROSENDAL, KAREN SOGAARD, MICHAEL KJAER,et al. Interleukin-6 of Human Interstitial Repetitive Low-force Exercise [J]. J Appl Physiol, 2004, doi: 10, 1152/japplphysiol,00130,2004.
5D C NIEMAN ,J M DAVIS,D A HENSON, et al. Carbohydrate Ingestion Influences Skeletal Muscle Cytokine mRNA and Plasma Cytokine Levels after a 3-h Run[J]. J Appl Physiol,2003,94(5):1917-1925.
6D C Nieman, J M DAVIS, V A BROWN,et al. Influence of Carbohydrate Ingestion on Immune Changes after 2h Intensive Resistance Training[J]. J Appl Physiol, 2004,96: 1292-1298.
7M H S CHAN,A L CAREY,M J WATT,et al. Cytokine Gene Expression in Human Skleletal Muscle during Concentric Contraction: Evidence that IL-8, Like IL-6, Is Influenced by Glycogen Availability [J]. Am J Physiol Regulatory Integrative Physiol, 2004,287(2):R322-R327.
8JONSDOTTIR Ⅰ SCHJERLING, P OSTROWSKI, K ASP S RICHTER. et al. Muscle Contractions Induces Interleukin-6 mRNA Production in Rat Skeletal Muscles [J]. J Physiol, 2000,528,157-163.
9A STEENSBERG, M A FEBBRAIO, T OSADA, et al.Interleukin-6 Production in Contracting Human Skeletal Muscle is Influenced by Pre-exercise Muscle Glycogen Content[J]. J Physiol,2001,537(2) :633-639.
10DE ROSSI, M BERNASCONI, P BAGGI,et al. Cytokines and Chemokines are Both Expressed by Human Myoblasts :Possible Relevance for the Immune Pathogenesis of Muscle Inflammation[J]. Int Immunol, 2000,12 : 1329-1335.