摘要
目的 了解贺斯（Hydroxyethyl starch，HAES—Steril）溶液对伴高度水肿的肾病综合征患者的利尿扩容作用。方法 10例原发性或继发性肾病综合征伴有重度双下肢浮肿和／或腹水患者，以6％贺斯溶液500ml加呋塞米20～80mg静脉滴注治疗7d，观察尿量、体重、肾功能、凝血功能、血清白蛋白、血清淀粉酶及电解质等的变化。结果 自滴注贺斯当日起，患者尿量即明显增加并持续至治疗结束，BUN、SCr治疗后较治疗前略有升高（P〉0．05），血清淀粉酶治疗后明显升高（P〈0.01），而血压和出、凝血指标维持正常，患者无明显不适表现。结论 贺斯作为胶体代血浆用品可有效治疗肾病综合征患者的水肿，且无明显副作用.
Objective To investigate the effect of HAES - Steril solution on blood volume expansion and diuresis in patients with nephrotic syndrome. Methods 10 patients with primary or secondary nephrotic syndrome accompanied by severe edema of lower limbs and/or ascites were treated by infusing intravenously 6% HAES - Steril solution 500 milliliter daily for 7 days, followed by injection of furosemide 20 - 80 mg. The output of urine, bodyweight, renal function, prothrombin time （PT）, kaolin partial thromboplaslin time （ KPTT ）, scrota albumin, serum amylase, and electrolytes were measured during the course. Results The volume of urine increased significantly once after HAES - Steril solution were infused （898 ± 261ml/d vs 2280 ± 342ml/d ,before perfusion versus after perfusion, （P 〈 0.01 ） and remained increased during the treatment. Blood urea nitrogen （ BUN ） and serum creatitine （ SCr ） were elevated slightly after treatment but had no significance （P 〉 0.05 ）. Serum amylase was increased significantly （P 〈 0.01 ）. Blood pressure （BP） and coagulation index remained unchanged and the patients had no discomfort. Conclusion As a substitute of plasma, HAES - Steril solution may effectively relieve edema of the patients with nephrotic syndrome. Meanwhile, no marked side effect was observed.
出处
《浙江临床医学》
2006年第7期695-696,共2页
Zhejiang Clinical Medical Journal
关键词
贺斯溶液
肾病综合征
尿量
HAES - Steril solution nephrotic syndrome volume of urine
