摘要
目的:观察α-2b干扰素在侵袭性恶性淋巴瘤(NHL)中的治疗作用及不良反应。方法:天津医科大学附属肿瘤医院肿瘤内科自1999年10月至2003年4月,共治疗52例侵袭性恶性淋巴瘤(NHL)。分为单用CHOP组及α-2b干扰素+CHOP组(简称干扰素组),各26例。CHOP组:环磷酰胺600mg/m2,iv,d1;表阿霉素60～70mg/m2,iv,d1;长春新碱1.2mg/m2,iv,d1;阿赛松50mg/m2,口服,d1～5。干扰素组:化疗方案同前,加用干扰素300万单位,2～3次/周,皮下注射或肌肉注射,于化疗休息期间进行。结果:CHOP组CR7例(26.9%),PR12例(46.2%),CR+PR19例,总有效率为73.1%,干扰素组CR9例(34.6%),PR14例(53.8%),CR+PR23例,总有效率为88.4%。不良反应干扰素组流感样症状发热及骨、肌肉痛明显高于CHOP组,两组比较有统计学差异(P<0.05)。结论:α-2b干扰素+CHOP较易耐受,且在缓解率及缓解期方面均有优于化疗组的迹象,其治疗非霍奇金淋巴瘤价值已经临床及基础研究证实。值得进一步研究观察。
Objective： To evaluste the effect of Interferon in treating middle to high degree NHL （Non Hodgkins Lymphoma）. Methods： From October 1999 to April 2003,52 cases of nuddle to high degree NHL were treated in Tianjin Cancer Research Institute and Hospital, one group use only CHOP regimens were single CHOP and CHOP with Interferon（INF）. Results： The group of single CHOP With response of CR 7 cases （26.9%）, PR 12 cases （46.2%）, RR 19 cases （73.1%）, The another group using CHOP regimen combined Interferon, got a response of CR 9 cases（34.6%）, PR 14 cases （53.8%）, RR 23cases （88.4%）.0.250〉P〈0.100. Side effects ：Group of combination with Interferon is gently in bone marrow depression, but with fever and pain of intramuscular-osseous superior to another group, P〈 0.05. Conclusion： This method in easy to be practiced in clinic with good response .
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第13期765-767,共3页
Chinese Journal of Clinical Oncology
