摘要
目的对比拉莫三嗪和卡马西平治疗新就诊的部分性发作癫患者的效果。方法随机将43例新就诊的部分性发作癫患者,分别给予拉莫三嗪(A组)和卡马西平(B组)治疗,观察发作控制情况及生活质量改善情况。结果A组总有效率为90.5%(19/21),B组总有效率为90.9%(20/22),两组差异无统计学意义。A组治疗后QOLIE-31量表评分为(66±17)分,B组治疗后为(52±16)分,两组比较差异有统计学意义(P<0.05)。结论拉莫三嗪与卡马西平治疗部分性发作癫患者的效果相当,能较卡马西平更好地改善癫患者的生活质量,提示拉莫三嗪可作为治疗部分性发作癫的一线药物。
Objective To investigate the efficacy of lamotrigine （LTG） with carbamazepine （CBZ） in newly diagnosed partial epilepsies. Methods Open - label randomized comparative 12 - week monotherapy trial in newly diagnosed epilepsy patients of ≥ 16 years of age. Fourty - three patients with epilepsy enrolled into the study and were divided into A group （treated with LTG） and B group （ treated with CBZ）. The primary efficacy variable was the number of seizure - free patients in 12 - week study. Quality of life was measured with the 31 - item quality of life inventory in epilepsy （ the QOLIE - 31 ） scale. Results The percent of the CBZ patients became seizure - free and that of the LTG patients were not statistically different . The QOLIE - 31 scales of two groups were signiticant difference, P 〈 0. 05. Conclusion This study indicates that the effectiveness of LTG in partial epilepsy as initial monotherapy in patients ≥16 years is in the range of standard first- line antiepileptic drugs.
出处
《中国医师进修杂志（内科版）》
2006年第7期26-27,共2页
Chinese Journal of Postgraduates of Medicine
