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2型糖尿病患者胰岛素抵抗与胰高血糖素的关系 被引量：7

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摘要 目的探讨2型糖尿病患者胰高血糖素变化与胰岛素抵抗的关系。方法2型糖尿病患者33例(糖尿病组)、正常对照者30例(正常对照组),行口服75g葡萄糖耐量试验,分别于0、30、60、120min取静脉血,测定血糖、胰岛素、胰高血糖素。结果①糖尿病组30、60、120min胰高血糖素水平均明显高于正常对照组(P<0.05或P<0.01)。②糖尿病组稳态型评价胰岛素抵抗(HOMA-IR)明显高于正常对照组(P<0.01)。③HOMA-IR与空腹胰岛素,葡萄糖耐量试验60min后胰高血糖素60及胰高血糖素60/胰岛素60水平呈正相关(r值分别为0.64、0.61、0.79,P<0.05或P<0.01)。结论2型糖尿病患者胰高血糖素升高,胰高血糖素可能是胰腺α细胞对胰岛素抵抗的标志。
作者 冯海英 丁焕然 史视明
机构地区 华北煤炭医学院 唐山市协和医院
出处 《中国综合临床》 北大核心 2006年第8期707-708,共2页 Clinical Medicine of China
关键词 2型糖尿病 胰高血糖素 胰岛素抵抗 胰腺α细胞
分类号 R587.1 [医药卫生—内分泌]
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参考文献7

  • 1Larsson H,Ahren B.Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagon secretion in postmenopausal women with impaired glucose tolerance[J].Diabetes Care,2000,23 (5):650-657.
  • 2Taylor R,Magnusson I,Rothman DL,et al.Direct assessment of liver glycogen storage by 13 nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects[J].J Clin Invest,1996,97(1):126-132.
  • 3Ferrannini E,Simonson DC,Katz LD,et al.The disposal of an oral glucose load in patients with non-insulin-dependent diabetes[J].Metabolism,1988,37 (1):79-85.
  • 4Shah P,Vella A,Basu A,et al.Lack of suppression of glucagons contributes to postprandial hyperglycemia in type 2 diabetes mellitus[J].J Clin Endol Metab,2000,85 (11):4 053-4 059.
  • 5李军,李秀钧,张杰,罗梅,周桥,赵桂芝.糖耐量受损大鼠胰岛α细胞胰高血糖素及神经肽Y的表达[J].中华内分泌代谢杂志,2004,20(3):185-189. 被引量：31
  • 6安雅莉,李光伟,刘雪丽,潘琳.胰岛细胞抗体亚型与胰岛素、胰高血糖素分泌的关联[J].中华内分泌代谢杂志,2004,20(3):190-192. 被引量：9
  • 7廖二元 超楚生.内分泌学[M].北京：人民卫生出版社,2001.610-611.

二级参考文献23

  • 1Kisanuki K, Kishikawa H, Araki E, et al. Expression of insulin receptor on clonal pancreatic alpha cell and its possible role for insulin-stimulated negative regulation of glucagons secretion. Diabetologia, 1995,38:422-429.
  • 2Kaneko K, Shirotani T, Araki E, et al. Insulin inhibits glucagon secretion by the activation of PI3-kinase in In-R1-G9 cells. Diabetes Res Clin Pract, 1999,44:83-89.
  • 3Winter WE, Maclaren NK, Riley WJ, et al. Pancreatic alpha cell autoantibodies and glucagon response to arginine. Diabetes, 1984,33:435-437.
  • 4Borg H, Gottsater A, Landing-Olssom M , et al. High level of antigen-specific islet antibodies predict future β-cell failure in patients with onsetof diabetes in adult age. J Clin Endorinol Metab, 2001,86:3032-3038.
  • 5Zamaklan M, Jotic A, Lalic N, et al. Relation between course of disease in type 1 diabetes and islet cell antibodies. Ann N Y Acad Sci, 2002,958:251-253.
  • 6Lefebvre PJ. Glucagon and its family revisited. Diabetes Care, 1995,18:715-730.
  • 7Greenbaum CJ, Prigeon RL, D′Alessio DA. Impaired beta-cell, function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose . Diabetes, 2002; 51: 951-957.
  • 8Umpaichitra V, Bastian W,Taha D, et al. C-peptide and glucagons profiles in minority children with type 2 diabetes mellitus. J Clin Endocrinol Metab, 2001,86:1605-1609.
  • 9Larsson H, Ahren B. Islet dysfunction in insulin resistance involves impaired insulin secretion and increased glucagons secretion in postmenopausal women with impaired glucose tolerance. Diabetes Care, 2000,23:650-657.
  • 10Shah P, Basu A, Basu R, et al. Impact of lack of suppression of glucagon on glucose tolerance in humans. Am J Physiol, 1995,277:E283-E290.

共引文献700

同被引文献73

引证文献7

二级引证文献31

中国综合临床
2006年 第8期

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