摘要
为比较不同处理的同种异体骨移植的免疫反应，作者用新鲜骨、自消化抗原去除骨、骨基质明胶和脱钙骨基质分别植入小鼠肌肉，行免疫学和组织碱性磷酸酶检测。结果：同种异体新鲜骨引发宿主抗体水平最高，在体外明显刺激淋巴细胞增殖；而后三种移植物引发的宿主抗体水平较低，在体外抑制淋巴细胞增殖。结论：免疫排异抑制移植物成骨，骨诱导活性物质抑制免疫反应。
Theimmunnologicrejectioninducedbydiferentlytreatedalograftsofbonewascom-pared.MethodsFreshbone(FB),autolyzedantigen-freebone(AAA),bonematrixgelatin(BMG),demineralizedbonematrix(DBM)wereimplantedintothemusclepouchofmice,then,theimmunologi-caltestsandalkalinephosphataseassaywereconducted.ResultsAlogeneicFBinducedthehighestlevelofserumantibodyinthehostandstimulatedlymphocytesproliferationremarkablyinvitro;incontrast,AAA,BMGandDBMcausedlowtiterofantibodyandinhibitedlymphocytesreproductioninvitro.Con-clusions.Immunologicalrejectionrestrainedosteogenesisoftheboneimplant,whereastheosteoinduc-tivesubstanceofbonesuppressedimmunologicalreaction.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1996年第8期460-463,共4页
Chinese Journal of Surgery
关键词
骨移植
抗原
免疫反应
移植免疫学
BonetransplantationAntigenImmunologicalreactionTransplantationim-munology
