摘要
AIM： To investigate the role of transglutaminase 3 （TGM3） gene in human esophageal squamous cell carcinoma （ESCC）, and analyze its relationship with clinicopathological parameters. METHODS： Gene expression of TGM3 in fresh esophageal cancer tissues and their corresponding normal mucosas was detected immunohistochemically（I HC） by means of tissue microarray（TMA）. Its correlation with clinical characteristics was evaluated and analyzed by univariate analysis. All statistical analyses were performed by SPSS version 10.0. RESULTS： Expression rate of TGM3 was reduced to 81.8% in ESCC. Expression of TGM3 was significantly inversely correlated with histological grade of esophageal carcinoma （in grade I, II and III tumors, the reduced expression was 4/7, 57/71, and 20/21, respectively, P 〈 0.05）, whereas it had no obvious correlations with lymph node metastasis and depth of invasion. CONCLUSION： Reduced expression of TGM3 may play an important role in esophageal carcinogenesis.
瞄准：调查 transglutaminase 的角色 3 (TGM3 ) 在人的食道的有鳞的房间癌(ESCC ) 的基因，和分析它与 clinicopathological 参数的关系。方法：在新鲜食道的癌症纸巾和他们的相应正常 mucosas 的 TGM3 的基因表示组织化学地是检测免疫(IHC ) 借助于织物微数组(TMA ) 。它与临床的特征的关联被 univariate 分析评估并且分析。所有统计分析被社会科学统计套装软体版本 10.0 执行。结果：TGM3 的表示率在 ESCC 被归结为 81.8% 。TGM3 的表示相反地显著地与食道的癌的组织学的等级被相关(在等级我， II 和 III 肿瘤，分别地，减少的表示是 4/7， 57/71，和 20/21 P < 0.05 ) ，而它没与淋巴节点转移和侵略的深度有明显的关联。结论：TGM3 的减少的表示可以在食道的致癌作用起一个重要作用。
基金
Supported by National Key Program on Basic Research, No.2004CB518604
