摘要
AIM： To investigate the influence of a positive proximal margin in total gastrectorny patients with gastric adenocarcinorna of the cardia. METHODS： Medical records of 191 patients with total gastrectornies for adenocarcinorna of the cardia between 1995 and 2000 were reviewed. The clinicopathologic features associated with a positive margin were determined, and the predictors for survival were analyzed. RESULTS： The incidence of positive proximal margin was 8.4% （16/191）. The positive margins were associated with advanced diseases. The tumor size and the depth of tumor invasion were independent risk factors for a positive margin. The mean survival in the positive margin group was 33.9 mo as compared.with 62.4 mo in the negative group （P 〈 0.001）. However, the difference in survival lost significance in subgroup analysis according to stage. Multivariate analysis identified that a positive margin was not an independent prognostic factor for survival. CONCLUSION： A positive margin is more of an indication of advanced disease in patients with gastric adenocarcinoma of the cardia rather than an independent prognostic factor for survival.
瞄准：与贲门的胃的腺癌在全胃切除术病人调查积极近似边缘的影响。方法：有为在 1995 和 2000 之间的贲门的腺癌的全部的 gastrectomies 的 191 个病人的医药记录被考察。与积极边缘联系的临床病理特征被决定，并且为幸存的预言者被分析。结果：积极近似边缘的发生是 8.4%(16/191 ) 。积极边缘与病沉重期被联系。肿瘤尺寸和肿瘤侵略的深度是为积极边缘的独立风险因素。在积极边缘组的吝啬的幸存作为与在否定的组的 62.4 瞬间相比是 33.9 瞬间(P < 0.001 ) 。然而，在幸存的差别根据舞台在亚群分析失去了意义。Multivariate 分析鉴别积极边缘不是为幸存的一个独立预示的因素。结论：积极边缘为幸存是在有贲门而非一个独立预示的因素的胃的腺癌的病人的病沉重期的一个指示的更多。
基金
Supported by the Korean Science and Engineering Fund through the Cancer Metastasis Research Center at Yonsei University
