摘要
为了了解食管癌患者肿瘤中郎格罕细胞（ＬＣ）的分布与预后的关系，作者对１６７例连续手术切除的食管鳞癌组织标本，用免疫组化（ＡＢＣ）方法Ｓ－１００蛋白染色，观察了ＬＣ在肿瘤癌巢内、癌巢周、间质内、癌旁粘膜及淋巴滤泡五个不同部位中的形态、数量及分布特点，以及与病理分期的关系；对随访３年以上的１２７例，观察了癌组织不同部位中ＬＣ的数量与存活时限的关系。结果发现ＬＣ在癌巢内及淋巴滤泡中的数量，随食管癌的ＴＮＭ分期增大而明显增多，Ⅲ、Ⅳ期病变癌巢内的ＬＣ均值比Ⅱ期者显著增值，呈正相关。由此提示，癌巢内ＬＣ增多的患者生存期较短；而癌巢周、癌旁粘膜及间质内ＬＣ增多的患者生存期较长。这两点可作为判定患者预后的免疫学方面的新指标。
Theoperativetumorspecimenofesophagealsquamouscarcinomawerestudiedwithim-munohistochemical(ABC)methodS-100proteinstaining.Underthelightmicroscopy,weobservedthemorphology,numberanddistributionofLangerhan'scels(LC)indiferentportionofthetumormassanditsrelationshipwiththepathologicalstagingin167cases.Weobservedalsotherelationshipbe-tweenLCandthepostoperativesurvivalperiodin127casesfolowedformorethan3years.Thesere-sultssuggestedfoundthatpositiverelationbetweenthenumberofLCinthecancernestandinthelym-phfoliclewiththeincreasingofTNMclassification.ThenumberofLCinthecancernestsignificantlyincreasedinstageⅢandⅣcasesthanstageⅡcases.Onthecontrary,thenumberofLCintheperi-tumorandinterstitialtissuedecreasedwhiletheTNMclassificationwasincreasing.Thesefindingssug-gestedthatthesurvivalperiodwasshorterinpatientswhoseLChadincreasedinthecancernest,whereasthesurvivalperiodwouldbelongerinthosepatientswhoseLChadincreasedinthetissuearoundthetumormass,inthemucosanearthetumoraswelasintheinterstitialtissue.Thesetwopointsmightbeusedasanimmunologicalpara-meterfortheassessmentoftheprognosis.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1996年第7期430-432,共3页
Chinese Journal of Surgery
关键词
食管肿瘤
郎格罕细胞
鳞癌
EsophagealneoplasmsPrognosisLangerhanscel
