摘要
作者测定了１１７例鼻咽癌患者外周血ＮＫ细胞活性水平，并与４０例健康者进行比较，结果发现鼻咽癌患者外周血ＮＫ细胞活性低于对照组（Ｐ＜０．０１），低分化鳞状细胞癌、未分化细胞癌患者ＮＫ细胞活性显著低于中分化鳞状细胞癌和对照组（Ｐ＜０．０５和Ｐ＜０．０１）；ＵＩＣＣ－ＴＮＭ分期Ⅱ、Ⅲ、Ⅳ期和复发病例的ＮＫ细胞活性均数各为２５．７５±１４．６３、２４．７０±１２．４２、１９．１５±８．２９、１５．６５±７．２５，Ⅳ期和复发者显著低于Ⅱ、Ⅲ期者（Ｐ＜０．０５）。血ＮＫ细胞活性与鼻咽癌患者血清ＥＢ病毒ＶＣＡ－ＩｇＡ抗体水平呈负相关（γｓ＝－０．８５，Ｐ＜０．０５）。结果表明鼻咽癌患者外周血ＮＫ细胞活性受抑制，并随病情进展而下降。作者认为检测外周血ＮＫ细胞活性可作为评估鼻咽癌预后的一项辅助指标。
The levels of natural killer cell activity(NK-CA) in the blood were determined in 117 patients with nasopharyngeal cancer and 40 healthy controls. The levels of NK-CA in the blood were significantly lower in patients than those in the control subjects(P<0.01). The NK-CA patients with moderately differentiated squamous cell cancer was significantly higher than that in patients with poorly differentiated squamous cell cancer and with undifferentiated cell cancer(P<0. 05 and P<0. 01 ,respectively). The mean levels of NK-CA in patients with TNM stages Ⅱ、Ⅲ、Ⅳand in those with recurrence were 25 . 75±14. 63,24. 70±12. 42,19. 15±8. 29,15. 65±7. 25 respectively(P<0. 05 ).A negative correlationship between the levels of EB-virus VCA-IgA antibody and the level of NK-CA in the blood was detected(P<0.05). The result has suggested that NK-CA in the blood in patients with nasopharyngeal cancer was depressed and thus lowered as the disease developed. The authors conclude that NK-CA in the blood might be regarded as one of the subsidiary factors for prognosis of nasopharyngeal cancer.
关键词
鼻咽肿瘤
免疫学
NK细胞
Killer cells, natural/blood
Nasopharyngeal neoplasms/immunol
