摘要
４８只雄性昆明种小白鼠分为四组，肝损伤组（１２只）给予ＣＣｌ４皮下注射；肝损伤盐水组（１２只）除给予ＣＣｌ４外，用生理盐水灌胃７天；治疗组（１２只）除给予ＣＣｌ４外，用枸杞多糖（ＬＢＰ）灌胃７天；对照组（１２只）皮下注射生理盐水，自来水灌胃。结果治疗组与损伤组及损伤盐水组相比，肝小叶损伤区域缩小，肝细胞中脂滴减少，细胞核增大，ＲＮＡ及核仁增多，糖原增加，ＳＤＨ、Ｇ—６—Ｐａｓｅ活性增强，粗面内质网恢复平行排列，线粒体形态结构恢复，数量增加。表明枸杞多糖对肝损伤有修复作用，其机理可能是通过阻止内质网的损伤，促进蛋白质合成及解毒作用，恢复肝细胞的功能。
Kunming mice were divided into four groups.The liver damage group (n=12) was poisoned via hypodermal injections(hdi)with CCl 4;The liver damage saline group (n=12) was poisoned via hypodermal injections(hdi) with CCl 4 and normal saline was administered daily through gastric intubastion(gt) for 7 days;The treated group(n=12) was given “LBP” through gastric intubation(gt) for 7 days immediately following CCl 4 hdi.The control group(n=12) was administered with normal saline hdi and tap Water gt.The result showed that the treated group displayed mild liver damage.In hepatic lobule the necrotic area and the liver cellular fat droplets decreased,while RNA,nucleole,glycogen increased,SDH and G-6-Pase activity increased as well,and the rough endoplasmic reticulum recovered to normal range,the mitochondria regained the normal structure and increased in number.According to this observation,it is suggested that the “LBP”be able to prevent the damage of endoplasmic reticulum and to promote protein synthesis and detoxication.Hence it recover the liver function and promote hepatocellular regeneration.
出处
《宁夏医学杂志》
CAS
1996年第4期196-198,共3页
Ningxia Medical Journal
关键词
枸杞多糖
肝损伤
四氯化碳
形态学
Lycium barbarum polysadccharides(LBP)
Liver damage
CCl 4
Morphological study
