摘要
报导肿瘤坏死因子（ＴＮＦ）与家兔日本血吸虫病肝纤维化形成的关系。结果提示，当成虫排卵后血清肿瘤坏死因子含量开始增加，与对照组差异有高度显著性（Ｐ＜００１）。肿瘤坏死因子含量增加的同时，肝汇管区的胶原纤维分布面积百分比亦相应增加，当肝组织已形成假小叶时，肿瘤坏死因子含量呈下降趋势（ｒ＝０６４３，Ｐ＜００１）。表明肿瘤坏死因子含量与肝纤维化的形成相关。作为细胞因子，ＴＮＦ可能对血吸虫性肝纤维化的形成有重要作用。
This paper reported an experimented study on the relationship of TNF and schistosoma hepatic fibrosis. The results showed that the content of TNF in the schistosoma_infected rabbits was higher than that of normal control( P <0 01), At the same time, the variation of the liver tissue was very distinguished, the collagen and the percentage of collagen distribution in liver in the schistosoma japonicum_infected rabbits was higher than in the normal control( P <0 01). So the author indicated that the TNF might play an importent role in the schistosomiasis hepatic fibrosis.
基金
湖北省血吸虫防治委会课题资金
