摘要
目的：探讨创伤患者单核细胞ＨＬＡ－ＤＲ抗原表达在创伤感染发生机制中的作用．方法：严重创伤患者２４例按临床结果分为创伤组（ｎ＝１７）和创伤感染组（ｎ＝７），于入院后第１、３、７天和１４天取血测定单核细胞ＨＬＡ－ＤＲ抗原表达率和血浆ＴＮＦ含量．结果：两组患者伤后第１天单核细胞ＨＬＡ－ＤＲ表达率分别为０．３２±０．０７和０．２６±０．１１，显著低于正常对照（０．６０±０．０６），伤后第３天创伤组已恢复至０．５０±０．０８，而创伤感染组仍较低下（０．３４±０．１４）．两组均见ＴＮＦ的短暂升高．
Aim:ToevaluatetheroleofmonocyteHLA-DRantigenexpressioninthemechanismoftraumaticinfec┐tion.Methods:Twenty-fourseverelyinjuredpatientsweredividedintoanoninfectiongroup(n=17)andaninfectiongroup(n=7)accordingtotheoccurrenceofinfectionduringtheirstayinhospital.MonocyteHLA-DRantigenexpres-sionwasmeasuredonthe1st,3rd,7thand14thposttraumadays.Results:TheHLA-DRexpressiononthe1stpost-traumadaywas0.32±0.07inthenon-infectiongroupand0.26±0.11intheinfectiongroup.Bothweresignificantlylowerthanthatinnormalcontrols(0.60±0.06).Itreturnedto0.50±0.08onthe3rdposttraumadayinthenon-infec-tiongroup,butremainedlow(0.34±0.14)intheinfectiongroup.AtemporaryelevationofplasmaTNFlevelwasseeninbothgroups.Conclusion:MonocyteHLA-DRantigenexpressionplaysanimportantroleinthemechanismofpost-traumaticimmunologicaldisturbancesandinfection.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1996年第6期344-346,共3页
Chinese Journal of Trauma
关键词
创伤
感染
单核细胞
HLA-DR
抗原
表达
TraumaTraumaticinfectionMonocyteHumanLeukocyteAntigenDRAntigenexpression
