摘要
目的探讨鼻咽癌病人血清中血管内皮生长因子(vascurar endothelial growth factor,VEGF)表达水平与鼻咽癌发生及复发之间的关系。方法应用酶联免疫吸附法(ELISA)定量检测35例鼻咽癌初发者、9例鼻咽癌复发者、7例完全缓解者、10例慢性鼻咽炎病人、10例正常健康人及鼻咽癌上皮细胞株(HNE-1)培养上清液中VEGF含量情况。结果35例鼻咽癌初发者、9例鼻咽癌复发者血清及HNE-1培养上清液中VEGF含量较正常健康人对照组显著增高(P<0.01);而完全缓解者组VEGF含量与正常对照组及慢性鼻咽炎病人比较无统计学意义(P>0.05);HNE-1培养上清液中VEGF含量与培养的鼻咽癌细胞数有一定相关性(P<0.05,r=0.657)。结论血清VEGF水平检测可作为诊断鼻咽癌发生、复发的观测指标之一。
Objective To investigate the relationship between serum VEGF level and the carcinogenesis or relapase of nasopharyngeal carcinoma （NPC）. Methods The VEGF levels in the sera from 35 primary NPC patients, 9 relapsed NPC patients, 7 complete remiasion patients, 10 chronic nasopharyngotis patients and 10 healthy control group and HNE-1 cell cultured supematants were measured by sandwich ELISA. Results The serum VEGF concentrations of primary NPC, relapsed NPC patients and HNE-1 cell cultured supematants were significantly higher than of the healthy control group and the complete remiasion group （ P 〈 0.01 ）, but there were no significant difference between the remission group and the control group （ P 〉 0.05） and there were linear correlation between the VEGF concentration and the count of HNE-1 cells cultured （ r = 0. 657, P 〈 0.05）. Conclusion The serum VEGF level of patients with nasopharyngeal carcinoma appears to be a predictor of the carcinogenesis or relapse of nasopharyngeal carcinoma.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2006年第3期179-181,共3页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
