摘要
目的探讨注意缺陷多动障碍(ADHD)与多巴胺-β-羟化酶基因(DBH)第5内含子Taq I酶切多态性的关系。方法依据DSM-IV诊断标准,选取76例ADHD核心家系,采用以家系为基础的遗传统计学方法研究DBH的Taq I等位基因A1、A2和基因型(A1/A2,A2/A2,A1/A1)的分布不同,探讨两者之间有无显著性差异。结果以单体型相对风险的方法分析DBH内含子Taq I等位基因A1、A2传递结果χ2=3.09 P>0.05,基因型比较χ2=3.39 P>0.05。提示DBH多态性与ADHD关联不显著,但有增加ADHD患病趋势。根据传递不平衡检验分析DBH内含子Taq I等位基因A1、A2传递结果P=0.136,提示Taq I的两个等位基因在ADHD患儿的传递中差别不显著,可能A2等位基因有增加ADHD患病的趋势。结论DBH内含子Taq IA2等位基因可能增加注意缺陷多动障碍患病的趋势。
Objective To investigate the correlation between the polymorphism of dopamine beta hydroxylase gene （DBH）and attention deficit hyperactivity disorder（ADHD）. Methods Seventy - six children with ADHD were diagnosed according to the DSM - IV criteria. DNA was extracted to examine the DBH Taq I （A1, A2） and genotype （A1/A2,A2/A2,A1/A1） polymorphism. Results Haplotype based haplotype relative risk results showed no significant difference（ x^=3.39 P 〉 0.05 ; x^2 = 3.09 P 〉 0.05 ） between the ADHD patients and DBH Taq I. Transmission disequilibrium test results（ P = 0.136） showed no significant difference between the ADHD patients and DBH Taq I A2. But it had a tendency to be associated with ADHD. Conclusion DBH Taq I A2 has a tendency to be associated with ADHD.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第12期764-765,共2页
Journal of Applied Clinical Pediatrics
关键词
注意缺陷伴多动障碍
多巴胺口羟化酶
基因
多态现象
attention - deficit hyperactivity disorder
dopamine beta hydroxylase
gene
polymorphism
