摘要
目的:探讨肿瘤坏死因子-α(TNF-α)与子痫前期-子痫患者胰岛素抵抗的关系。方法:分别检测38例子痫前期-子痫患者(研究组)及34例正常健康孕妇(对照组)空腹胰岛素、血糖及血清TNF-α水平,用胰岛素敏感指数(ISI)反映机体胰岛素抵抗程度。结果:研究组空腹血清TNF-α及胰岛素分别为18.34±7.54pg/m l、16.55±4.56mU/L明显高于对照组的9.13±4.41pg/m l、10.38±2.94mU/L(P<0.05),ISI(取自然对数)研究组为-3.84±0.59,显著低于对照组的-3.46±0.45,差异有统计学意义(P<0.05),TNF-α与ISI呈显著负相关(r=-0.476,P<0.05)。结论:子痫前期-子痫患者胰岛素抵抗程度增加,可能与血清TNF-α水平升高有关。
Objective：To study the relationship between tumor necrosis factor-α（TNF-α） and insulin resistance in pre-eclampsia and eclampsia patients. Methods： Fast serum TNF-α,insulin and blood glucose levels were detected in both pre-eclampsia eclampsia patients（ the study group） and the healthy pregnant women （ the control group）. Insulin sensitive index （ ISI ） was used to show body insulin sensitivity. Results：The serum TNF-αand insulin average levels were higher in study group（ 18.34 ＋ 7.54pg/ml, 16.55 ± 4.56mU/L）than that in the control group（9.13 ± 4.41pg/ml, 10. 38 ＋ 2.94mU/L） （P 〈 0. 05 ）. ISI was lower in study group （ - 3.84±0.59 ） than that in the control group （ - 3.46 ＋ 0.45 ） （ P 〈 0.05 ）. There was significant negative correlation between serum TNF-α level and ISI （ r = - 0.476, P 〈 0.05 ）. Condusion：The higher level of insulin resistance in pre-eclampsia and eclampsia patients may be related to the increased serum TNF-α level.
出处
《现代妇产科进展》
CSCD
北大核心
2006年第5期362-364,i0002,共4页
Progress in Obstetrics and Gynecology
