摘要
目的用自己设计的胃粘膜活检组织切片美蓝染色法检查Hp,研究Hp感染与消化不良等症状的关系,及Hp感染与胃粘膜慢性炎症、消化性溃疡等病理改变的关系。方法对32例无症状者及476例有消化不良等症状者在进行内镜检查及常规病理活检的同时,对组织切片行美蓝染色检查Hp,对无症状组及各疾病组的Hp检出率进行比较。结果美蓝染色方法简单,效果好。Hp感染在无症状人群中达43.7%,其中胃粘膜活检有慢性炎症改变者Hp检诊达85.7%;胃粘膜病理活检正常者Hp检出率为6.3%。慢性胃炎及消化性溃疡的Hp检出率分别为54.5%及48.9%。结论 Hp感染与镜下胃粘膜炎症改变相关而不一定有消化不良症状。Hp感染可引起慢性胃炎、消化性溃疡等胃粘膜病变。
AIMS With a methyleneblue section-stain of the gastromucosal biopsy, the relation of Hp infection to the dyspepsia and the pathologic changes of gastromucosa, eg. chronic endogastritis, peptic ulcer etc was studied. METHODS The gastroscopy and routine biopsy were comPleted in 32 patients without the symptoms and 476 with dyspepsia. Hp was detected with the methyleneblue sectionstain of gastromucosal biopsy tissue simul tanenously. Detectable rate of Hp in asymptiomatic group was compared with that in each disease group. RESULTS The methyleneblue stain was characterized by simPlicity and effectiveness. Infectious rate of Hp recached 43.7% in asymptomatic group, and 85.7% with the chronic gastritis by gastromucosal biopsy in asymptomatic group, 6.3% with normality by gastromucosal biopsy. Detectable rates of Hp in patients with chronic gastritis and peptic ulcer were 54.4% and 48.9% respectiviely. CONCLUSIONS Infection of Hp is related with gastritis, but not associated with dyspepsia. Infection of Hp could initiate gastromucosal pathologic change.
关键词
幽门螺杆菌
感染
美蓝染色法
临床应用
Helicobacter pylori gastritis peptic ulcer dyspepsia stains and staining
