摘要
目的:通过实验研究心肌多肽提高小鼠抗疲劳作用和耐缺氧能力和探讨可能的生物机制。方法:采用昆明种小鼠,分低、中、高剂量组,经口灌胃给予心肌多肽30 d,剂量分别为0.5 g/kg/d,1.0 g/kg/d,2 g/kg/d,另设蒸馏水对照组。观察小鼠负重游泳时间,耐缺氧能力,并测定抗疲劳相关生化指标:血乳酸、血中尿素氮含量、肝糖原含量以及血红细胞和肝脏中的超氧化物歧化酶(SOD)活力。结果:心肌多肽的中、高剂量组均能延长小鼠负重游泳时间以及耐缺氧能力。并且小鼠运动后血乳酸、血中尿素氮含量与对照组相比明显降低,肝糖原含量明显高于对照组,并且小鼠的血红细胞和肝脏中的超氧化物歧化酶(SOD)活力明显高于对照组。结论:心肌多肽具有增强小鼠抗疲劳和耐缺氧的能力。
Objective： To study and discuss the anti - fatigue effects and biological mechanism of cardiac polypeptides. Methods： Cardiac polypeptides was administered to mice in treated group for 30 days by 0.5 g/kg/d, 1.0 g/kg/d, 2.0 g/kg/d respectively, and the changes of exhaustive swimming time and the bear anoxia ability were measured. Then biochemical index were measured which includes blood lactic acid, urea nitrogen, liver glycogen and the activities of superoxide dismutase （SOD） of Hb and liver in the mice. Results： Compared with control group, the exhaustive swimming time and bear anoxia ability of the administered mice in treated group were significantly longer, while the SOD activities of Hb and live in mice obviously increased. And the content of hepatic glycogen increased obviously while the content of blood lactate, and blood urea nitrogen decreased significantly. Conclusion： The cardiac polypeptides have a potential anti - fatigue effect and anti - oxidative capability.
出处
《现代预防医学》
CAS
北大核心
2006年第7期1097-1099,共3页
Modern Preventive Medicine
关键词
心肌多肽
抗疲劳
生物机制
小鼠
Cardiac polypeptides
Anti-fatigue
Biological mechanism
Mice
