摘要
目的探讨紫杉醇为主的联合化疗方案在晚期上消化道恶性肿瘤患者中的治疗价值。方法回顾性分析2000年以来我们应用以紫杉醇为主的联合化疗方案治疗晚期上消化道恶性肿瘤患者56例的临床资料，胃腺癌41例，食管鳞癌15例。所有病例人院后化疗至少2周期，一般给予2—6周期，平均3、11周期，均可评价客观疗效。结果CR4例，PR20例，NC20例，PD12例，有效率（CR＋PR）为42、9％（24／56）；胃癌有效率为46．3％（19／41），食管癌为33．3％（5／15）；TP方案化疗有效率为40.0％（14／35），TCF方案化疗有效率为47．6％（10／21）。结论紫杉类药物联合化疗对上消化道癌有效，且TCF方案疗效优于TP方案，值得临床应用。
Objective To evaluate the efficacy of combined chemotherapy based on paclitaxel in treatment of patients with advanced upper gastrointestinal cancers, Methods The clinical data of 56 patients with advanced upper gastrointestinal cancers who have received combined chemotherapy based on paclitaxel since 2000 were retrospectively analyzed. Of all the patients ,41 cases were stomach adenocarcinoma and 15 were esophagus All cases received 2 to 6 cycles of chemotherapy based on paclitaxel,with average of 3, 11 cycles, Results The overall response rate was 42.9% （ CR 4 cases, PR 20 cases, NC 20 cases, PD 12 cases）,with 46. 3% （19/41） in stomach cancer patients and 33.3% （5/15） in esophagus cancer patients, The response rates of TP and TCF combined chemotherapy were 40. 0% （ 14/35 ） and 47. 6% （ 10/21 ） respectively. Conclusions The combined chemotherapy based on paclitaxel is effective in patients with upper gastrointestinal cancers. The curative effect of TCF regimen surpasses that of TP regimen and deserves further clinical application.
出处
《中国肿瘤临床与康复》
2006年第3期244-246,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
消化道恶性肿瘤/化学疗法
紫杉醇
Digestive system malignant neoplasm/chemotherapy
Paclitaxel
