摘要
目的探讨鼻咽癌放射治疗后舌下神经损伤的临床特点、诊断、治疗、预后及影响其发生的相关因素。方法对我院1990年4月至2004年7月发现的66例鼻咽癌放射治疗后舌下神经损伤患者的临床资料进行回顾性分析。结果45例患者在早期用激素、抗生素、大量维生素等药物治疗，13例症状轻微改善，26例无明显变化，6例病情进展。随访59例，死亡22例，现生存26例。出现神经损伤后生存0．5～14年。结论放射性舌下神经损伤缺乏特异性的治疗手段，它的发生与照射剂量、照射体积、照射技术及分次剂量等因素有关，预防颈部纤维化可减少放射性舌下神经损伤的发生。
Objective To study the clinical features, diagnosis, treatment and prognostic factors and causes of radiation-induced hypoglossal nerve injury in patients with nasopharyngeal carcinocma. Methads Sixty-six patients with radiation-induced hypoglossal nerve injury in this hospital during the period from April 1990 to July 2004 were analyzed retrospectively. Results Forty-five patients were treated with dexamethasone ,antibiotics and vitamin etc, with symtoms slightly relieved in 13 patients ,unimproved in 26 patients and becoming worse in 6 patients. Fifty-nine patients were followed up. Of them,22 patients died and 26 patients are still alive. The surviving time after appearance of nerve injury was 0.5 to 14 years. Conclusions Radiation injury of hypoglossal nerve has no effective treatment methods. The incidence of radiation-induced hypoglossal nerve injury is related to irradiation dose, irradiation volume, radiotherapy technique and fractional dose. Radiation induced-fibrosis of the neck is the risk factor associated with radiation-induced hypoglossal nerve injury.
出处
《中国肿瘤临床与康复》
2006年第3期225-227,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
鼻咽肿瘤
舌下神经
放射损伤
Nasopharyngeal neoplasms
Hypoglossal nerve
Radiation injury
