摘要
目的描述POEMS综合征的临床特点,以提高对此病的认识。方法报道8例POEMS综合征患者临床表现、实验室检查及治疗方法并复习有关文献。结果8例患者均有周围神经病变,其中4例患者血有M-蛋白,症状复杂多样。对8例患者进行不同尝试的治疗,结果症状有一定改善。结论POEMS综合征是一少见的多系统损害疾病,发病机制不很清楚,常有多发性神经病、脏器肿大、内分泌病、M-蛋白和皮肤改变症状。早期病例易被误诊,临床应认真分析、检查,以提高临床检出率。
Objective To describe the clinical features of POEMS （polyneuropathy, organomedaly, endocrinopathy, M protein and skin changes） syndrome for an insight into this syndrome. Methods Eight cases of POEMS syndrome were reviewed. The clinical features, laboratory inspections, pathogenesis, relevant therapeutics and the outcome of 8 cases of POEMS syndrome were reviewed. Resnlts All 8 cases had perpheral polyneuropathy. In addition, 4 cases had M-proteins, especially with complicated symptom diversity. The diagnosis of POEMS syndrome was made based on the clinical features and laboratory findings according to POEMS syndrome. Eight cases were treated with different therapeutic regimens and the symptoms were improved subsequently. Conclusions POEMS syndrome is a rare multisystem disorder of obscure pathogenesis with some symptom complexes including polyneuropathy, organomegaly, endocrinopathy, M-proteins and skin changes. The pathogenesis of POEMS syndrome remains to be clarified and clinical characteristics are variform, which easily leads to misdiagnosis in early stage. More attention should be paid to it for improving the accuracy of diagnosis and adequacy of the treatment.
出处
《中国神经免疫学和神经病学杂志》
CAS
2006年第4期227-229,共3页
Chinese Journal of Neuroimmunology and Neurology
