摘要
目的研究胃食管反流患者的食管下括约肌压力(LESP)及胃电图的变化。方法检测胃食管反流患者(分为症状性反流和反流性食管炎)及对照组的LESP和胃肌电活动的频率及振幅。结果症状性反流及反流性食管炎患者的LESP均明显低于对照组;胃食管反流患者的胃肌电活动频率显著低于对照组;胃肌电频率正常者的LESP高于频率降低者。结论 LESP低下者易发生胃食管反流;症状性反流应作为胃食管反流病(GERD)的一个阶段;异常的胃肌电活动与食管下括约肌功能的减退及胃食管反流病的发生有关。
AIMS To investigate the changes of the lower esophageal sphincter pressure(LESP) and electrogastrogram(EGG) in patients with gastroesophageal reflux(GER). METHODS LESP and the frequency and the amplitude of gastric myoelectrical activity were measured in patients with GER (subdivided into symptomatic GER(n=1) and esophagitis(n=15) and healthy controls(n=14). RESULTS LESP in symptomatic reflux and esophagitis were significantly lower than that in controls. There was a slower frequency of ECG in GER patients than that in controls. Sub. jects with normal frequency had a higher LESP than those with slow frequency. CONCLUSIONS People with lower LESP are liable to suffering from GER; Symptomatic reflux is a stage of GERD; Abnormal gastric myolectrical activity is related to impairment of LES function and occurencc of GERD.
关键词
胃食管反流
食管
括约肌
胃电图
gastroesophageal reflux
electrogas-trography
esophagitis
