胃癌胃良性病变患者血清和局部组织中IL—I水平及意义

Interleukin-1 level of serum and tissue in patients with gastric cancer, gastric benign diseases and its clinical signifiance

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摘要目的探讨白细胞介素－Ｉ（ＩＬ—Ｉ）的水平与胃癌发病的关系。方法应用生物反应测定法对２７例胃癌、１５例胃溃疡、１６例慢性表浅性胃炎，１８例慢性萎缩性胃炎及２２例正常人的血清和组织培养上清液ＩＬ—Ｉ活性进行进行了测定．结果胃癌患者血清和组织中ＩＬ—Ｉ水平均低于正常人，也低于胃良性病变组；胃溃病组织中ＩＬ—Ｉ水平低于正常人，但高于胃癌组织。结论胃癌的发生可能与ＩＬ—Ｉ水平低下有关。胃溃汤组织中ＩＬ－Ｉ低下可能是其癌变的因素之一。 Objective The aim of this study was to investigate the relationship between IL-1 level and gastric cancer.Methods Using a reliable biological assaying method to measure the activity of IL-1 of serum and tissue in 27 cases of gastric cancer, 15 cases of gartril ulcer, 16 cases of chronic superficial gastritis 18cases of chroric astrophic gastritis and 22 normal subjects.Results Serum and tissue activity of IL-1 in gastric cancer (27cases) were significantly lower than normal controls (P<0.01 ); The activity of IL-1 in tissue of gastric ulcer; 15 cases) were lower than normal controls (P<0. 05), but higher than gastric caacer (P<0.05).Conclusion There were a relationship between the lower activity of IL-1 and gastric cancer. In the tissue of gastric ulcer IL-1 activity was lower, this might be a cause of why gastric ulcer predisposes to gastric malignancy.