摘要
报告三种非侵入性胃泌酸功能试验在消化性溃疡（PU）病人中的应用，并与常用的五肽胃泌素刺激试验进行比较．口服金属镁胃酸呼气氢测定结果表明，十二指肠球部溃疡（DU）患者（18例）氢气产生量明显高于健康对照者（10例），且与胃溃疡（GU）病人（27例）有显著差异性（P＜0．01）。H2受体阻滞剂治疗DU（15例）后，氢气产生量明显下降．19例浅表性胃窦炎患者99m锝扫描结果与基础及总产氢量呈正相关性（γ＝0．9664，P＜0．001）。尿天青A含量测定，DU患者（14例）排出量明显高于正常人（21例）及胃癌患者（21例）（P＜0.01）。上述三种试验与插管法五肽胃泌素刺激试验相比均有显著相关性。
Determination of gastric acidity without intubation in patients with peptic ulcer,chronic gastritis and gastric cancer was studied. First,we consistently detected significant increase in breath and belching of hydrogen following magnesium metal (150mg) ingestion in the pentagastrin-stimulated duodenal ulcer patients (n=18) as compared to the patients with gastric ulcer (n=27) and normal controls (n= 10). This response was blocked by ranitidine treatment. The amount of hydrogen released in patients.with chronic gastritis (n= 21) was significantly lower than that in normal controls. Second, pentagastrin-stimulated intragastric activity of 99mTc (lmci) correlated with acid output as measured by means of breath bydrogen analysis following magnesium administration. Third,replacement of ingestion of a nontoxic dyf,azure A,its ion exchangable compound (0. 4g) by gastric acid became remarkably higher in patients with duodenal ulcer (n=14) as compared to normal controls (n= 21) and those with gastric cancer (n = 21). All these three tubeless techniques were well correlated with the comrponly used intubation method and pentagastrin stimulation test. We conclude that the principle of these tubeless techniues might be able to develop some simple noninvasive tests for gastric acid analysis.
出处
《江苏医药》
CAS
CSCD
1996年第8期519-521,共3页
Jiangsu Medical Journal
关键词
胃泌酸功能试验
五肽胃泌素
消化性溃疡
Pentagastrin Azure A hydrogen breath test magnesium ^(99m)Tc Peptic ulcre
