摘要
采用对大鼠主动免疫２次，乙醇、去氧胆酸钠溶液与热水灌胃连续６０天的综合方法，诱发大鼠实验性萎缩性胃炎，随后进行３０天麦滋林－Ｓ治疗后，处死大鼠，测定各组动物胃液游离酸及胃粘膜的病理改变，结果表明，生理盐水模型组胃液游离酸含量及胃粘膜病理改变（粘膜变薄、腺体减少、炎细胞浸润及肠腺化生），与正常组比较均有显著变化（Ｐ＜０．０ｌ或Ｐ＜０．０５）而麦滋林－Ｓ颗粒对大鼠萎缩性胃炎有部分逆转治疗作用。
After twice active immunity,40% alcohol,20mmol/L sodium deoxycholate,50℃distilled water were administered to SD rats for 8 weeks to induce a rat-model of chronic atropic gastritis,Marzulene- S po for 4 weeks.The rats were killed and their gastric free acid and the pathologic change of the gastric mucosa were assayed.The results suggested that the gastric free acid and the pathologic change of the gastric mucosa were significantly variation between the normal control group and the model control group (P<0.0l or P<0.05):Marzulene-S was effective in the reverse therapy for the chronic atropic gastritis in SD rats
出处
《华西药学杂志》
CAS
CSCD
北大核心
1996年第2期78-80,共3页
West China Journal of Pharmaceutical Sciences
