摘要
根据某些含氧、氮的希夫碱及其金属螯合物有明显的抗癌抑菌作用，为寻找新的抗癌抑菌药物设计合成了５－硝基－Ｎ－（２－羟基乙基）水杨醛亚胺希夫碱Ⅰ．氯（硝酸、乙酸）５－硝基－Ｎ－（２－羟基乙基）水杨醛亚胺合铜Ⅱ和双５－硝基－Ｎ－（２－羟基乙基）水杨醛亚胺合铜Ⅴ四种新化合物。其组成与结构已由元素分析和红外光谱所表征。初步抑菌试验表明化合物Ⅰ、Ⅱ、Ⅲ对多种细菌有抑菌活性。
The chelates of 5-nitro-N-[2-hydroxyethyl]salicylaldimine Schiff base with copper [Ⅱ] have been synthesized and characterized by elementary analysis and infrared spectral data.These chelates are new metal complexes of Schiff base type.They have been tested for their antibacterial activities.The results showed that some chelates displayed antibacterial activities in the primary treatment of many types of bacteria
出处
《华西药学杂志》
CAS
CSCD
北大核心
1996年第2期69-71,共3页
West China Journal of Pharmaceutical Sciences
