摘要
目的观察前列腺素E1(PGE1)对肺心病心力衰竭患者的临床疗效及对肺动脉压力的影响。方法将40例肺心病患者随机分为两组,治疗组25例,在心衰的常规治疗基础上加用PGE1 200 mg/d,共14 d;对照组15例,为心衰常规治疗。观察治疗前后各组及组间心功能分级、心率、超声心动图及肺动脉压力的变化。结果各组治疗后较治疗前相比心功能均有不同程度的改善,但治疗组更为明显,差异有显著性。同时治疗组肺动脉压力显著降低。结论前列腺素E1对肺心病心力衰竭患者有明显疗效,同时能显著降低肺动脉压力,使用方便安全。
Objective To evaluate clinical therapeutic effects of lipo - prostaglandin El （ PGE1 ） on Cur Pulmonale with heart failure and Pulmonary Hypertension. Methods 40 patients with Cor Pulmonale were randomly divided into a treatment group（ n=25, Lipo PGE1 20＆micro i g/ day, 14days, iv drip add conventional therapy） and a control group （ n = 15, conventional therapy ）. The changes of clinical manifestation （ NY- HA functional class）, heart rate, echocardiography and pulmonary pressure were measured before and after treatment. Results The improvement of NYHA class and echoeardiography were significant in both group, the more significant in the treatment group, The puhnonary pressures were decreased significantly in the treatment group. Conclusion The effects of Lipo PGE1 on heart failure and pulmonary pressure of Cor Pulmonale are remarkable and safety.
出处
《临床和实验医学杂志》
2006年第6期679-680,共2页
Journal of Clinical and Experimental Medicine
关键词
前列腺素E1
肺心病
心力衰竭
肺动脉压力
LiFo-prostaglandin E1
Cor Puhnonale
Heart Failure
Pulomonary Pressure
