摘要
目的:研究αcat、βcat和Ecad在食管癌组织中的表达及临床意义。方法:应用免疫组织化学SP法检测αcat、βcat和Ecad在100例食管癌组织中的表达。结果:αcat、βcat和Ecad的异常表达率分别为48%、51%和57%。αcat的表达与浸润深度、淋巴结转移、TNM分期和分化程度有关,u值分别为2.835、2.602、2.660和2.893,P值分别为0.005、0.009、0.008和0.004;βcat的表达与浸润深度、淋巴结转移、TNM分期和分化程度有关,u值分别为4.566、3.095、2.484和3.578,P值分别为0.000、0.002、0.013和0.000;Ecad的表达与浸润深度、淋巴结转移、TNM分期和分化程度有关,u值分别为2.851、3.811、2.958和3.130,P值分别为0.004、0.000、0.003和0.002。αcat、βcat和Ecad正常表达患者的5年生存率高于异常表达者,χ2值分别为6.83、5.34和13.39,P值分别为0.009、0.021和0.000。食管癌组织中Ecad和αcat、βcat之间表达差异均无统计学意义,χ2值分别为2.37和1.25,P值分别为0.130和0.320。结论:αcat、βcat和Ecad的异常表达与食管癌发生发展有关,测定其表达情况可作为预测食管癌的生物学行为和预后的重要指标之一。
OBJECTIVE.. To study the expressions and significance of α-catenin, α-catenin and E-cadherin in esophageal carcinoma. METHODS： The expressions of α-catenin, β-catenin and E-cadherin were detected by the immunohistochemical technique （S-P method） in 100 cases of esophageal carcinoma. RESULTS： The abnormal expression rates of α-cat, β-cat and E-cad were 48%, 51% and 57%, respectively. The expression of α-cat was correlated with infiltrative depth, lymphatic metastasis, the time of TNM and differentiation （u values were 2. 835, 2. 602, 2. 660 and 2. 893 respectively and P values were 0. 005, 0. 009, 0. 008 and 0. 004 respectively）. The expression of β-cat was correlated with infiltrative depth, lymphatic metastasis, the time of TNM and differentiation （u values were 4. 566, 3. 095, 2. 484 and 3. 578 respectively and P values were 0. 000, 0. 002, 0. 013 and 0. 000 respectively）. The expression of E-cad was correlated with infiltrative depth, lymphatic metastasis, the time of TNM and differ- entiation （u values were 2. 851, 3. 811, 2. 958 and 3. 130 respectively and P values were 0. 004, 0. 000, 0. 003 and 0. 002 respectively）. The 5-year survival rate in cases of normal expression of α-cat, β-cat and E-cad were significantly higher than that in cases of abnormal expression （X^2 valus were 6.83, 5.34 and 13.39 respectively and P values were 0. 009, 0. 021 and 0. 000 respectively）. The differences of expression among E-cad, a-cat and β-cat in esophageal carcinoma were not significant （X^2 values were 2.37 and 1.25 respectively and P values were 0. 130 and 0. 320 respectively）. CONCLUSIONS： The abnormal expressions of α-cat, β-cat and E-cad are related to occurrence and development of esophageal carcinoma. They may serve as valuable indication for biological behavior and prognosis in esophageal carcinoma.
出处
《中华肿瘤防治杂志》
CAS
2006年第10期752-755,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
福建省教育厅科研基金项目(JA03161)
