摘要
目的 研究信号转导和转录激活因子6（STAT6）基因多态性与哮喘易感性的关系。方法 通过数据库检索文献，确定文献纳入和排除标准，筛选文献，进行异质性检验和Hardy—Weinberg平衡检验，并确认文献的发表偏倚，然后应用Meta分析固定效应模型对STAT6 G2964A基因多态性与哮喘关系的文献进行定量综合分析。结果 共入选3篇文章，累计病例443例，其中STAT6基因突变阳性287例，对入选的3篇文献进行异质性检验，P〉0．05，文献没有异质性，合并OR值为0．81，合并OR值的95％可信区间为0．59～1．11。结论 通过本次研究，STAT6 G2964A基因多态性与人群哮喘易感性可能没有明显相关性。
Objective To study the association of the signal transducer and activator of transcription 6（STAT6） G2964A polyrnorphisms and asthma. Methods To search the database for related studies, make inclusion and exclusion criteria and heterogeneity test and Hardy - Weinberg equilibrium test. The studies of STAT6 gene polymorphisms and asthma were analyzed with fixed effect mode Meta - analysis. Results There were three articles selected with 443 asthma patients. Among them, there were 287 with STAT6 gene mutation. Total OR was 0.81, and 95% CI was 0.59-1.11. Conclusion The polymorphisms of STAT6 G2964A may not have definitely related with asthma.
出处
《实用预防医学》
CAS
2006年第3期511-512,共2页
Practical Preventive Medicine
基金
第三军医大学科研基金资助项目(XG200523)
