摘要
脂蛋白（ａ）［Ｌｐ（ａ）］是一种与低密度脂蛋白类似的脂蛋白，其特殊处在于多含一种具明显多态性的糖蛋白──载脂蛋白（ａ）［Ａｐｏ（ａ）］。Ａｐｏ（ａ）与血浆纤溶酶原有很大同源性。Ｌｐ（ａ）由肝合成，其分解可能主要经非特异途径。Ａｐｏ（ａ）大小及血浆Ｌｐ（ａ）浓度主要由Ａｐｏ（ａ）基因决定。Ｌｐ（ａ）易沉积于血管壁，并可促进平滑肌细胞生长及抑制纤维蛋白溶解，这可能是其促动脉粥样硬化和血栓形成的机理所在。Ｌｐ（ａ）的生理功能尚不清楚。
Lipoprotein(a)(Lp(a)is a LDL-like lipoprotein with an additional highly polymorphic glycoprotein──apolipoprotein(a)(apo(a).Apo(a)bears great homology with plasminogen,Lp(a)is synthesized by liver and its degradation may be carried out by a nonspecific process. Apo(a)isoform size and plasma Lp(a)levels are mainly determined by apo(a)gene. Lp(a)can easily be deposited in arterial wall.It promotes growth of smooth muscle cells and inhibits fibrinolysis.These could be the mechanisms by which Lp(a)accelerates atherosclerosis and thrombosis. The physiological role of Lp(a)has not been clearly understood.
出处
《生理科学进展》
CAS
CSCD
北大核心
1996年第1期25-30,共6页
Progress in Physiological Sciences
关键词
脂蛋白
载脂蛋白
心脏血管疾病
Lipoprotein(a)
Apolipoprotein(a)
Plasminogen
Polymorphism
Kringle
