摘要
目的探讨p16基因和p21基因表达异常对膀胱癌预后的影响。方法以“bladder carcinoma”或“bladder neoplasm”、“prognosis”、“p16”/“p21”和“膀胱癌”、“预后”等为检索词,检索Medline、PubMed、中国生物医学文献及中国学术期刊数据库有关p16基因和p21基因表达异常与膀胱癌预后的文献,应用Meta分析Dersimonian-Laird模型对这些文献进行综合定量评价。结果纳入Meta分析的19篇文献累计病例1584例,阳性率40.4%；其中p16基因表达异常12篇,累计病例975例,阳性率37.4%；p21基因异常表达7篇,累计病例609例,阳性率45.4%。p16基因表达异常、p21基因表达异常、p16基因和p21基因表达异常与膀胱癌预后的合并RH值分别为3.70(95% CI 3.42～3.99)、3.01(95% CI2.81～3.21)和3.18(95% CI 3.01～3.35)。结论p16基因和p21基因表达异常是膀胱癌患者预后不良的生物标记物,有助于膀胱癌的治疗决策。
Objective To investigate the correlation of p16 gene and p21 gene expression abnormal- ity with the prognosis of bladder carcinoma. Methods Using the search terms ＂bladder neoplasm＂, ＂prognosis＂ ,＂p16＂ or ＂p21＂ ,the literature on the correlation of p16 gene and p21 gene expression abnormality with the prognosis of bladder carcinoma were searched from MEDLINE database,PubMed database, CBMdisc and China Academic Periodical database, and were evaluated by Meta-analysis with DersimonianLaird model. Results A total of 19 trials involving 1584 patients （positive rate of 40.4% ） were identified,including 12 trials of 975 patients （positive rate of 37.4% ） on p16 gene expression abnormality and 7 trials of 609 patients （positive rate of 45.4% ） on p21 gene expression abnormality. The combined relative hazard （RH） of p16 gene expression abnormality on the prognosis of bladder carcinoma,p21 gene expression abnormality on the prognosis of bladder carcinoma and both p16 gene and p21 gene expression abnormality on the prognosis of bladder carcinoma was 3.70 （95% CI,3.42 - 3.99） ,3.01 （95% CI,2.81 - 3.21 ） and 3.18（95% CI,3.01 -3.35）,respectively. Conclusions Both p16 gene and p21 gene expression abnormalities are biomarkers for poor prognosis of bladder carcinoma. The detection of these biomarkers may be helpful in making the treatment strategy.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2006年第6期400-403,共4页
Chinese Journal of Urology
关键词
膀胱肿瘤
癌
预后
META分析
Bladder neoplasms
Carcinoma
Prognosis
Meta-analysis
