摘要
目的:观察妊高征患者胎盘床肌层T淋巴细胞亚群的表达情况,探讨妊高征的免疫发病机制。方法:收集正常妊娠30例,妊高征患者60例,其中轻度28例,中度17例,重度15例,用免疫组化方法对妊高征和正常妊娠的胎盘床肌层浸润的淋巴细胞进行CD3、CD4、CD8的标记。结果:CD3在妊高征胎盘床肌层段浸润的淋巴细胞的表达与正常妊娠无明显差别(P>0.01),CD4在妊高征胎盘床肌层浸润的淋巴细胞的表达明显高于正常妊娠(P<0.05);CD8在妊高征胎盘床肌层浸润的淋巴细胞的表达明显低于正常妊娠(P<0.05)。结论:妊高征的发生与T淋巴细胞亚群的变化有着密切的关系,胎-母间免疫失衡是妊高征发病的重要因素。
Objective： To observe the expression of T-lymphocyte subpopulations in myoplacental bed in pregnancy with pre-eclampsia to explore the pathogenesis of pre-eclampsia . Method ： 30 cases of normal pregnancy were investigated in control group ; 60 cases of pre-eclampsia were investigated in study group,including 28 cases of mild pre-eclampsia, 17 cases of mediterate pre-eclampsia, 15 cases of sever pre-eclampsia. Immunohistochemical technique was used to mark the CD3,CD4,CD8 in lymphocyte infiltrating myo-placental bed in normal pregrancy and pre-eclampsia. Results ： There was no significant difference in expression of CD3 in lymphocyte infiltrated myo-placental bed between normal pregrancy and Pre-eclampsia. （P 〉 0. 05）. The expression of CD4 in lymphocyte infiltrated myo-placevtal bed of preeclampsia is higher than in normal pregnancy（P〈0.05）. The expression of CD8 in lymphocyte infiltratied myo-placental bed of pre-eclampsia was lower than normal pregnancy（P〈0. 05）. Conclusion ：The advance of pre-eclampsia is associated with the alteration of the T-lymphocyte subpopulation. The immune immbalance between fotel and mater play an important role in pre-eclampsia.
出处
《陕西医学杂志》
CAS
北大核心
2006年第6期649-651,共3页
Shaanxi Medical Journal
