摘要
对叔丁基杯[4]芳烃-1,3-二醛基衍生物1与水杨酰肼、烟酰肼、异烟酰肼反应,合成了具有开链结构新型杯[4]多重氮杂衍生物2a～2c,产率分别为88%,85%和90%.化合物1与乙二酰肼、丙二酰肼、己二酰肼反应,得到具有桥联结构的新型杯[4]多重氮杂衍生物3a～3c,产率分别为86%,89%和90%.新化合物的结构经元素分析、质谱、核磁共振谱等表征证实,杯[4]芳烃单元均为1,3-取代且采取锥式构象.
The reaction of p-tert-butylcalix[4]-1,3-substituted benzaldehyde derivative 1 with salicylic hydrazide, nicotinic hydrazide or isonicotinic hydrazide gave a series of novel ring opening calix[4]arene derivatives 2a～2c containing polyaza groups in the yields of 88%, 85% and 90%, respectively. Treatment of compound 1 with oxalyl dihydrazide, malonic dihydrazide and adipic dihydrazide, afforded novel bridged calix[4]arene derivatives 3a～3c substituted with polyaza groups in the yields of 86%, 89% and 90%, respectively. All new compounds were characterized by elemental analyses, ESI-MS, ^1H NMR spectra, which indicated that calix[4]arene units were 1,3-substituted pattern with cone conformation.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2006年第6期866-869,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20402002)
福建省自然科学重点基金(No.E0220002)资助项目.
