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B细胞激活因子在免疫调节中的作用 被引量：6

Role of B-Cell-Activating-Factor in Immune Regulation—Review
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摘要 B细胞激活因子(BAFF)是调节B淋巴细胞存活和成熟的细胞因子,属于TNF家族成员。BAFF有三个受体,分别为BCMA,TACI和BAFF-R。近几年来的研究表明,BAFF及其受体在抗体类型转换、生发中心维持、T细胞共刺激等方面发挥着重要的免疫调节作用,对自身免疫疾病、淋巴瘤和B细胞免疫缺陷的治疗具有潜在的应用前景。本文就BAFF的结构与表达,BAFF受体,生物学功能及其临床应用作一综述。 B cell activating factor （BAFF） is one of the TNF family member, regulates the survival and maturation of B lymphocyte. BAFF binds to three receptors： BCMA, TACI and BAFF-R. In recent years, studies have revealed important roles of BAFF and its receptors in immune regulation of antibody isotype switching, germinal center maintenance, and T cell co-stimulation, that may provide new drugs in the future for the treatment of autoimmune disorders, lymphoma and B cell immunodeficiencies. Therefore, the structure, expression, receptors, biological function and clinical application of BAFF are briefly summarized in this review.
作者 杜建芳 王嘉玺 徐东刚
机构地区 军事医学科学院基础医学研究所分子遗传研究室
出处 《中国实验血液学杂志》 CAS CSCD 2006年第3期631-634,共4页 Journal of Experimental Hematology
基金 北京市自然科学基金资助 编号7042050
关键词 B细胞激活因子 B细胞激活因子受体 免疫调节 BAFF BAFF receptor immune regulation
分类号 R392.11 [医药卫生—免疫学]
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参考文献27

  • 1Moore PA,Belvedere O,Orr A,et al.BLyS:member of the tumor necrosis factor family and B lymphocyte stimulator.Science,1999; 285:260-263
  • 2Hahne M,Kataoka T,Schroter M,et al.APRIL,a new ligand of the tumor necrosis factor family,stimulates tumor cell growth.J Exp Med,1998; 188:1185-1190
  • 3Nardelli B,Belvedere O,Roschke V,et al.Synthesis and release of B-lymphocyte stimulator from myeloid cells.Blood,2001; 97:198-204
  • 4Scapini P,Nardelli B,Nadali G,et al.G-CSF-stimulated neutrophils are a prominent source of functional BLyS.J Exp Med,2003; 197:297 -302
  • 5He B,Chadburn A,Jou E,et al.Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL.J Immunol,2004; 172:3268-3279
  • 6Huard B,Arlettaz L,Ambrose C,et al.BAFF production by antigen-presenting cells provides T cell co-stimulation.Int Immunol,2004; 16:467-475
  • 7Hase H,Kanno Y,Kojima M,et al.BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex.Blood,2004;103:2257 -2265
  • 8Litinskiy MB,Nardelli B,Hilbert DM,et al.DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.Nat Immunol,2002; 3:822-829
  • 9Gavin AL,Ait-Azzouzene D,Ware CF,et al.Delta BAFF,an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine,BAFF.J Biol Chem,2003;278:38220-38228
  • 10Gavin AL,Duong B,Skog P,et al.deltaBAFF,a splice isoform of BAFF,opposes full-length BAFF activity in vivo in transgenic mouse models.J Immunol,2005; 175:319 -328

同被引文献57

  • 1王禹,王树杰,王力宁.狼疮性肾炎临床表现与病理改变的关系[J].中国医科大学学报,2006,35(4):408-409. 被引量：4
  • 2王燕,窦恒利,耿红莲,钱王争,梁艳,陆慧琦,朱烨,仲人前.增殖诱导配体在自身免疫病患者外周血中的表达[J].现代免疫学,2006,26(5):408-412. 被引量：2
  • 3李晓琳,侯宗柳（审校）.BAFF信号的免疫调节作用[J].国际免疫学杂志,2006,29(6):368-372. 被引量：5
  • 4梁艳,邓安梅,仲人前.NK细胞识别和杀伤机制研究进展[J].中国免疫学杂志,2007,23(3):284-287. 被引量：11
  • 5Wu KS, Hsiao CC, YU HR, et al. Helicobacter pylori infection and childhood idiopathic thrombocytopenic purpura [ J ]. Acta Paediatr Taiwan, 2007,48 ( 5 ) :263 - 266.
  • 6Cines DB, McMillan R. Pathogenesis of chronic immune thrombocytopenic purpura [ J ]. Curr Opln Hematol, 2007,14 ( 5 ) :511 - 514.
  • 7Zhang F, Chu X, Wang L, et al. Cell - mediated lysis of autologous platelets in chronic idiopathic thrombocytopenic purpura[J]. Eur J Haematol,2007,76 ( 5 ) :427 - 431.
  • 8Olsson B, Andersson PO, Jemas M, et al. T - cell - mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura [ J ]. Nat Med, 2007,93 ( 6 ) : 1123 - 1124.
  • 9Nardelli B, Belvedere O, Roschke V ,et al. Synthesis and release of B - lymphocyte stimulator from myeloid cells [ J 1. Blood, 2007,97 ( 2 ) : 198 -204.
  • 10Do RK, Hatada E, Lee H, et al. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response [ J ]. Exp Med ,2000,192 ( 7 ) :953 - 964.

引证文献6

二级引证文献22

中国实验血液学杂志
2006年 第3期

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