摘要
免疫性血小板减少性紫癜(immunethrombocytopenicpurpura,ITP)是一种较为常见的自身免疫病,其临床试验多建立于临床药物的应用,而非亚临床研究,有可能因为意外并发症被迫中止,因此建立理想的动物模型有助于加深对I5发病机制和用药机理的理解。本综述回顾了ITP模型的发展过程,总结了被动型和主动型造模方法在ITP研究中的应用,尤其是转基因小鼠可更好模拟人类疾病病理状态,有利于进一步探讨新的诊断和治疗方法。
Human ITP clinical trials have been performed based on observations of clinical uses of drugs, other than on mechanism studies in preclinical models, many studies were stopped because of unexpected complications. So there was need to develop ideal animal model of ITP to improve the understanding of the pathophysiology and the mechanisms of action of therapeutics. In this review, the history of animal models of ITP was retrospected, two modeling methods inducing passive and active models, especially transgenic rice model which can more accurately represent human disease pathophysiology, and their application in study of ITP were summarized. An animal model for human immune thrombocytopenia allows detailed studies of the mechanism, kinetics, and therapy of human immune thrombocytopenia.
出处
《中国实验血液学杂志》
CAS
CSCD
2006年第3期623-626,共4页
Journal of Experimental Hematology
基金
国家自然科学基金资助项目
编号:30300312
30470742
