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感觉神经肽P物质特异性受体在表皮干细胞上的表达 被引量:2

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摘要 近10年来,表皮干细胞(epidermal stem cells,ESCs)作为皮肤细胞发生、修复、改建的源泉,因其与上皮源肿瘤、皮肤变应性疾病的发生密切相关而成为研究的热点。体内实验结果显示,皮肤伤口中外源性感觉神经肽P物质可促进ESCs增殖并将其大量募集于创缘,加速修复过程。为进一步探讨P物质对ESCs生物学行为影响的机制,本实验分别从蛋白水平和mRNA水平观察体外培养的ESCs上P物质的两种特异性受体:神经激肽1受体(NK—1R)和NK-2R的表达情况。
出处 《中华烧伤杂志》 CAS CSCD 北大核心 2006年第3期228-229,共2页 Chinese Journal of Burns
基金 国家重点基础研究发展规划资助项目(G1999054200)
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