摘要
在石油醚中,三氯化磷依次与二异丙基胺和苯甲醇反应,通过“一锅法”制备了磷脂化学中用途广泛的磷脂酰化试剂苄氧基-双(N,N-二异丙基氨基)膦。产物通过减压蒸馏纯化,以三氯化磷计,总收率达87.4%。工艺简单,重复性好,适合大量制备。
The phosphatidylative reagent benzyloxy-bis（N, N-diisopropyl-amino） phosphine used widely in phosphatide chemistry was prepared by ＂one-pot＂ method. It was synthesized from PCl3 via reaction with i-Pr2NH and BnOH successively in petroleum ether. The product was purified by distillation in vacuum. The total yield was 87.4% based on PCl3. The preparative method was advantageous in synthesis in large scale due to its simplicity and reproducibility.
出处
《化学试剂》
CAS
CSCD
北大核心
2006年第4期245-246,共2页
Chemical Reagents
